別名

1-octadecyl-sn-glycero-3-phosphate (ammonium salt); PA(18:0e/0:0)

測定

>99% (LPA; may contain up to 10% of the 2-LPA isomer)

一般描述

Lysophosphatidic?acid (LPA) is a class of phospholipids, which is water-soluble. It has a glycerol backbone attached?via?a phosphate group, an aliphatic chain and a hydroxyl group.?The aliphatic chain is linked to either?sn-1 or?sn-2 position and the phosphate group is connected to the?sn-3 position. The hydroxyl group is linked to the remaining?sn-1 or?sn-2?position.

應(yīng)用

C18 LPA or 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate may be used:
to study its effects on Yes-associated protein (YAP) phosphorylation as a standard for the quantification of lysophosphatidic?acid?(LPA)?compounds?in proton samples?using reversed-phase?ultra-performance?liquid chromatography-tandem mass spectrometer (UPLC-MS/MS) as a substrate to investigate the phosphatase activity of soluble epoxide hydrolase (sEH) towards LPA compounds

生化/生理作用

Lysophosphatidic?acid (LPA) is a signaling molecule and alters various cellular responses through G protein-coupled receptors (GPCRs). It stimulates smooth muscle contraction, cytoskeleton rearrangement and chemotaxis. LPA is also involved in inducing neurotransmitter release, cell proliferation, platelet aggregation and Ca2+ mobilization. Increased levels of LPA in human plasma leads to ovarian cancer and atherosclerosis. LPA acts as a potential biomarker for ovarian cancer.