Rabbit Anti-CD34 Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CD34
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:947
Swiss Prot:P28906
Source:Recombinant human CD34:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Background:The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:1000-2000)
ELISA(1:5000-10000)
IHC-P(1:50-200)
IHC-F(1:50-200)
ICC(1:50-200)
IF(1:50-200)
Cross Reactive Species:Human
Mouse
Rat
Dog
"僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： CD34;CD34 antigen;CD34 molecule;Cluster designation ;Hematopoietic;HPCA1;progenitor;CD34_HUMAN;
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