Rabbit Anti-MLC1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:MLC1
IR:Immunogen Range:321-377/377
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:23209
Swiss Prot:Q15049
Source:KLH conjugated synthetic peptide derived from human MLC1:321-377/377
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Horse
Rabbit
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： MLC1;KIAA0027;LVM;Membrane protein MLC;MLC; MLC-1;WKL1;MLC1_HUMAN;
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