Rabbit Anti-phospho-IKK beta (Ser471) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-IKK beta (Ser471)
IR:Immunogen Range:KN(p-S)MA
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3551
Swiss Prot:O14920
Source:KLH conjugated Synthesised phosphopeptide derived from human IKK beta around the phosphorylation site of Ser471:KN(p-S)MA
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Rabbit
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： phospho-IKK beta (Se;IKK beta (phospho S4; p-IKK beta (Ser471);IKBKB;IKKI kappa B kinase ;IKK2;IKKB;IKKB_HUMAN;
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