Rabbit Anti-ASK1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:ASK1
IR:Immunogen Range:321-460/1374
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:4217
Swiss Prot:Q99683
Source:KLH conjugated synthetic peptide derived from human ASK1:321-460/1374
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Flow-Cyt(3ug/Test)
Cross Reactive Species:Human
Mouse
Rat
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： ASK1;MAPK/ERK kinase kina;MEK kinase 5;MEKK 5;Apoptosis signal-reg;ASK-1;MAPKKK5;M3K5_HUMAN;
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