Rabbit Anti-Smac Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Smac
IR:Immunogen Range:151-239/239
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:56616
Swiss Prot:Q9NR28
Source:KLH conjugated synthetic peptide derived from human Smac:151-239/239
Purification:affinity purified by Protein A
Storage:Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. The inhibitor of apoptosis (IAP) proteins regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes their inhibitory effect on caspases has been designated Smac/DIABLO. This is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ICC(1:100)
Cross Reactive Species:Human
Mouse
Rat
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： Smac;Smac / Diablo;0610041G12Rik;DBOH;diablo;Drosophila;FLJ25049;DBLOH_HUMAN;
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