Rabbit Anti-phospho-JAK2 (Tyr221) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-JAK2 (Tyr221)
IR:Immunogen Range:IQD(p-Y)HI
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3717
Swiss Prot:O60674
Source:KLH conjugated synthesised phosphopeptide derived from human JNK2 around the phosphorylation site of Tyr221:IQD(p-Y)HI
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:JAK2 (Janus Activating Kinase 2) is a tyrosine kinase of the non-receptor type, that associates with the intracellular domains of cytokine receptors; JAK2 is the predominant JAK kinase activated in response to several growth factors and cytokines such as IL-3, GM-CSF and erythropoietin; it has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1007 and 1008 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/Test)
ICC(1:100)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Horse
Zebrafish
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： phospho-JAK2 (Tyr221;p-JAK2 (phospho Tyr2;JAK2 (phospho Y221);JAK2;Janus Kinase 2;JTK10;OTTHUMP00000043260;JAK2_HUMAN;
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