Rabbit Anti-phospho-PI3KCA (Tyr317) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-PI3KCA (Tyr317)
IR:Immunogen Range:TP(p-Y)MN
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5290
Swiss Prot:P42336
Source:KLH conjugated Synthesised phosphopeptide derived from human PI3KCA around the phosphorylation site of Tyr317:TP(p-Y)MN
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdInsP2. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Sheep
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： phospho-PI3KCA (Tyr3;PIK3CA(phospho Y317);PI3 kinase p110 subu;caPI3K;MGC142161;MGC142163;p110 alpha;PK3CA_HUMAN;
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