Rabbit Anti-phospho-IL7R (Tyr449) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-IL7R (Tyr449)
IR:Immunogen Range:EA(p-Y)VT
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3575
Swiss Prot:P16871
Source:KLH conjugated Synthesised phosphopeptide derived from human IL-7Ra around the phosphorylation site of Tyr449:EA(p-Y)VT
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Sheep
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(2ug/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： phospho-IL7R (Tyr449; IL-7Ra;Interleukin-7 recept;CD127;CD127 antigen;IL 7R alpha;IL7RA;IL7RA_HUMAN;
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