Rabbit Anti-PXR Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PXR
IR:Immunogen Range:51-150/434
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:8856
Swiss Prot:O75469
Source:KLH conjugated synthetic peptide derived from human PXR:51-150/434
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The human nuclear pregnane X receptor (PXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in mediating dangerous drug-drug interactions. The human PXR is related to the mouse Pxr1, which they had cloned and shown to be activated by dexamethasone, pregnenolone 16-alpha-carbonitrile (PCN), and other compounds known to induce expression of the CYP3A1 gene, the predominant form of CYP3A in rat liver and intestine. Northern blot analysis detected most abundant expression in liver, colon, and small intestine; transcripts of 2.6, 4.3, and 5 kb were present in each of these tissues.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Flow-Cyt(2ug/Test)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Horse
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： PXR;NR1I2;ONR1;Orphan nuclear recep;Orphan nuclear recep;Orphan nuclear recep;PAR;PAR2;
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