Rabbit Anti-Lpin1 protein Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Lpin1 protein
IR:Immunogen Range:201-300/924
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:14245
Swiss Prot:Q91ZP3
Source:KLH conjugated synthetic peptide derived from mouse Lpin1 protein:201-300/924
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism.
LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Mouse
Rat
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： Lpin1 protein;EC=3.1.3.4;KIAA0188;LPIN1;PAP1;LPIN1;HDLCQ11;LPIN1_MOUSE;
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