Rabbit Anti-WISP2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:WISP2
IR:Immunogen Range:171-250/2502
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:8839
Swiss Prot:O76076
Source:KLH conjugated synthetic peptide derived from human CTGFL:171-250/2502
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:WISP2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. WISP2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Rabbit
Sheep
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： WISP2;CTGFL;CCN family member 5;CCN5;CT58;CTGFL;Wisp2;WISP2_HUMAN;
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