Rabbit Anti-CD40/TNFRSF5 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CD40/TNFRSF5
IR:Immunogen Range:201-277/277
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:958
Swiss Prot:P25942
Source:KLH conjugated synthetic peptide derived from human CD40/TNFRSF5.:201-277/277
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Rabbit
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： CD40/TNFRSF5;B cell associated mo;TNFRSF5;B cell-associated mo;B-cell surface antig;Bp50;CD40 antigen;AI326936;
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