Rabbit Anti-SUR1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:SUR1
IR:Immunogen Range:301-400/1581
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:6833
Swiss Prot:Q09428
Source:KLH conjugated synthetic peptide derived from human SUR1:301-400/1581
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Horse
Guinea Pig
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： SUR1;ABC36;Abcc8;ATP binding cassette;HHF1;HRINS;MRP8;SUR;
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