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Anti-phospho-AKT1 antibody-磷酸化蛋白激酶B抗體,phospho-AKT1 (Ser129)
  • Anti-phospho-AKT1 antibody-磷酸化蛋白激酶B抗體,phospho-AKT1 (Ser129)

Anti-phospho-AKT1 antibody-磷酸化蛋白激酶B抗體

價格 1280 1980 2900
包裝 50ul 100ul 200ul
最小起訂量 50ul
發(fā)貨地 上海
更新日期 2024-11-07
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產(chǎn)品詳情

中文名稱:Anti-phospho-AKT1 antibody-磷酸化蛋白激酶B抗體英文名稱:phospho-AKT1 (Ser129)
品牌: 滬震生物產(chǎn)地: 中國/上海
保存條件: -20°C純度規(guī)格: > 99%
產(chǎn)品類別: 抗體 一抗
抗體名: AKT1 (phospho Ser129); p-AKT1 (phospho S129); AKT 1; AKT; AKT1; AKT-1; AKT1_HUMAN; C AKT; cAKT; MGC9965; MGC99656; Oncogene AKT1; PKB; PKB alpha; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC alpha serine/threonine protein kinase; RAC; RAC PK Alpha; Rac protein kinase alpha; RAC Serine/Threonine Protein Kinase; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; v akt murine thymoma viral oncogene homolog 1; vAKT Murine Thymoma Viral Oncogene Homolog 1. 靶點: 詳見說明書
宿主: Rabbit適應(yīng)物種: 詳見說明書
克隆性: 詳見說明書濃度: 1mg/ml
應(yīng)用范圍: WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.標(biāo)識物: 詳見說明書
形態(tài): 液體亞型: IgG1
免疫原: 詳見說明書貨號: Hz-R5188
用途范圍: 科研使用規(guī)格: 50ul/100ul/200ul
是否進口: 是否單克隆: 詳見說明書p55
保質(zhì)期: 12個月3抗原來源: 詳見說明書
標(biāo)記物: 詳見說明書產(chǎn)品用途: WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
2024-11-07 Anti-phospho-AKT1 antibody-磷酸化蛋白激酶B抗體 phospho-AKT1 (Ser129) 50ul/1280RMB;100ul/1980RMB;200ul/2900RMB 1280 滬震生物 中國/上海 -20°C > 99% 抗體 一抗

Host:Rabbit

Target Protein:phospho-AKT1 (Ser129)

IR:Immunogen Range:DN(p-S)GA

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:207

Swiss Prot:P31749

Source:KLH conjugated Synthesised phosphopeptide derived from human Akt1 around the phosphorylation site of Ser129:DN(p-S)GA 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
Flow-Cyt(2ug/Test)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Horse
.

搜狗截圖23年06月19日1006_19.png


本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用!


關(guān)鍵字: AKT;AKT1;AKT 1;AKT-1;AKT1_HUMAN;cAKT;MGC9965;PKB;

公司簡介

上海滬震實業(yè)有限公司是一家集研發(fā)、生產(chǎn)和銷售于一體的生命科學(xué)實驗室產(chǎn)品生物科技企業(yè)。主營產(chǎn)品:試劑盒,ELISA試劑盒,抗體,重組蛋白,血清,胎牛血清,細(xì)胞,原代細(xì)胞 細(xì)胞培養(yǎng)試劑,常用生化試劑。
成立日期 2014-05-08 (11年) 注冊資本 100萬元整
員工人數(shù) 10-50人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 生化試劑,細(xì)胞培養(yǎng),蛋白組學(xué),分子生物學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 工廠,試劑,定制,服務(wù)
  • 上海滬震實業(yè)有限公司
VIP 3年
  • 公司成立:11年
  • 注冊資本:100萬元整
  • 企業(yè)類型:有限責(zé)任公司(國內(nèi)合資)
  • 主營產(chǎn)品:ELISA試劑盒,抗體,細(xì)胞系,原代細(xì)胞,細(xì)胞培養(yǎng)試劑,重組蛋白
  • 公司地址:松江區(qū)
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