價格 | ¥1280 | ¥1980 | ¥2900 |
包裝 | 50ul | 100ul | 200ul |
最小起訂量 | 50ul |
發(fā)貨地 | 上海 |
更新日期 | 2024-11-07 |
中文名稱:Anti-phospho-AKT1 antibody-磷酸化蛋白激酶B抗體 | 英文名稱:phospho-AKT1 (Ser129) |
品牌: 滬震生物 | 產(chǎn)地: 中國/上海 |
保存條件: -20°C | 純度規(guī)格: > 99% |
產(chǎn)品類別: 抗體 一抗 | |
抗體名: AKT1 (phospho Ser129); p-AKT1 (phospho S129); AKT 1; AKT; AKT1; AKT-1; AKT1_HUMAN; C AKT; cAKT; MGC9965; MGC99656; Oncogene AKT1; PKB; PKB alpha; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC alpha serine/threonine protein kinase; RAC; RAC PK Alpha; Rac protein kinase alpha; RAC Serine/Threonine Protein Kinase; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; v akt murine thymoma viral oncogene homolog 1; vAKT Murine Thymoma Viral Oncogene Homolog 1. | 靶點: 詳見說明書 |
宿主: Rabbit | 適應(yīng)物種: 詳見說明書 |
克隆性: 詳見說明書 | 濃度: 1mg/ml |
應(yīng)用范圍: WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. | 標(biāo)識物: 詳見說明書 |
形態(tài): 液體 | 亞型: IgG1 |
免疫原: 詳見說明書 | 貨號: Hz-R5188 |
用途范圍: 科研使用 | 規(guī)格: 50ul/100ul/200ul |
是否進口: 否 | 是否單克隆: 詳見說明書p55 |
保質(zhì)期: 12個月3 | 抗原來源: 詳見說明書 |
標(biāo)記物: 詳見說明書 | 產(chǎn)品用途: WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
Host:Rabbit
Target Protein:phospho-AKT1 (Ser129)
IR:Immunogen Range:DN(p-S)GA
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:207
Swiss Prot:P31749
Source:KLH conjugated Synthesised phosphopeptide derived from human Akt1 around the phosphorylation site of Ser129:DN(p-S)GA
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
Flow-Cyt(2ug/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Horse
.
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用!
成立日期 | 2014-05-08 (11年) | 注冊資本 | 100萬元整 |
員工人數(shù) | 10-50人 | 年營業(yè)額 | ¥ 100萬以內(nèi) |
主營行業(yè) | 生化試劑,細(xì)胞培養(yǎng),蛋白組學(xué),分子生物學(xué),細(xì)胞生物學(xué) | 經(jīng)營模式 | 工廠,試劑,定制,服務(wù) |
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