Host:Rabbit

Target Protein:Phospho-HDAC3 (Ser424)

IR:Immunogen Range:KE(p-S)DV

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:8841

Swiss Prot:O15379

Source:KLH conjugated Synthesised phosphopeptide derived from human HDAC3 around the phosphorylation site of Ser424:KE(p-S)DV 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/Test)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat

                                                                                                                                                                                                                                                                                                                       本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！