Host:Rabbit
Target Protein:OPG
IR:Immunogen Range:201-300/401
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:4982
Swiss Prot:O00300
Source:KLH conjugated synthetic peptide derived from human OPG:201-300/401
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Osteoprotegerin (OPG, or osteoclastogenesis inhibitory factor) is a secretory glycoprotein belonging to TNF receptor superfamily. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. OPG acts as a soluble factor in the regulation of bone mass and may be beneficial in the treatment of osteoporosis with increased osteoclast activity. OPG consists of 401 amino acids with a molecular weight of 44 kDa as a monomer and 90 kDa as a disulphide-linked dimer.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)ELISA(1:5000-10000)IHC-P(1:100-500)IHC-F(1:100-500)ICC(1:100-500)IF(1:100-500)
Cross Reactive Species:HumanMouseRatDogRabbit
本產(chǎn)品僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷使用!
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