Host:Rabbit
Target Protein:HSD11B2
IR:Immunogen Range:151-250/405
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3291
Swiss Prot:P80365
Source:KLH conjugated synthetic peptide derived from human HSD11B2:151-250/405
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:200-1000)
ICC(1:100)
Cross Reactive Species:Human
Mouse
Rat
Dog
Horse
本產品僅供科研使用。不能用于人和動物治療等其它臨床診斷使用！
關鍵字： HSD11B2;HSD11K;HSD2; member 3;AME1;
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