20mg/mL分子量342.44質(zhì)量水平100儲(chǔ)存溫度2-8°CMDL" />
價(jià)格 | ¥2483.67 |
包裝 | 5 MG |
最小起訂量 | 1MG |
發(fā)貨地 | 上海 |
更新日期 | 2023-10-27 |
中文名稱(chēng):VU0240551 | CAS:893990-34-6 |
品牌: Sigma | 純度規(guī)格: ≥98% (HPLC) |
產(chǎn)品編號(hào) | V3890 |
品牌 | Sigma |
形式 | powder |
測(cè)定 | ≥98% (HPLC) |
溶解性 | DMSO: >20?mg/mL |
分子量 | 342.44 |
質(zhì)量水平 | 100 |
儲(chǔ)存溫度 | 2-8°C |
MDL編號(hào) | MFCD05957363 |
PubChem化學(xué)物質(zhì)編號(hào) | 329829046 |
別名
CID 7211972,N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide,SID 56405457,VU0240551-1,VU0240551-2-D4
生化/生理作用
VU0240551 is a potent, selective KCC2 inhibitor. KCC2 is a potassium-chloride exchanger expressed specifically in neurons. KCC2 functions to lower intracellular chloride concentrations below the electrochemical potential of the cells, thereby increasing the hyperexcitability of the neurons. KCC2 activity enhances GABA and other inhibitory neurotransmission and is implicated in pain processing. VU0240551 was discovered in a high-throughput screen, followed by directed medicinal chemistry. VU0240551 is selective for KCC2 over NKCC1. VU0240551 binds competitively to the K+ site and binds noncompetitively to the Cl- site. VU0240551 is the only small molecule with specificity for a KCC family member.
成立日期 | 2005-12-27 (20年) | 注冊(cè)資本 | 600.0萬(wàn)美元 |
員工人數(shù) | 100-500人 | 年?duì)I業(yè)額 | ¥ 1億以上 |
主營(yíng)行業(yè) | 分析化學(xué),材料化學(xué),生物化工,化學(xué)試劑,催化劑 | 經(jīng)營(yíng)模式 | 貿(mào)易,試劑,定制,服務(wù) |
產(chǎn)品名稱(chēng) | 價(jià)格 | 公司名稱(chēng) | 報(bào)價(jià)日期 | |
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¥332 |
VIP3年
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TargetMol中國(guó)(陶術(shù)生物)
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2024-12-12 |