別名

tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate,H₂N-PEG₄-CH₂CH₂COOtBu,H₂N-dPEG(4)-CO-OtBu

應(yīng)用

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

其他說明

Real-time monitoring of vesicle pH in an endocytic pathway using an EGF-conjugated two-photon probe

Development of Substrate-Selective Probes for Affinity Pulldown of Histone Demethylases

A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination