Rabbit Anti-Phospho-PTEN (Ser380 + Thr382 + Thr383) Polyclonal Antibody
Host:Rabbit
Target Protein:Phospho-PTEN (Ser380 + Thr382 + Thr383)
IR:Immunogen Range:RY(p-S)D(p-T)(p-T)DS
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5728
Swiss Prot:P60484
Source:KLH conjugated Synthesised phosphopeptide derived from human PTEN around the phosphorylation site of Ser380/Thr382/Thr383:RY(p-S)D(p-T)(p-T)DS
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Potential tumor suppressor. Acts as a phosphoinositide3-phosphatase by regulating PtdIns (3,4,5)P3 levels. Involved in regulation of the AKT1 signaling pathway. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation.The PTEN/MMAC1 discovers the first to have the suppress of the phosphoric acid enzyme activity cancer gene currently.The gene of PTEN locates the chromosome10q23 area, sending forth sex tumor and a few households cancers with the variety to suffer from the comprehensive disease easilyrelevant.The activity that passes to repress the Akt regulates the cell period, the cell ground rule decease and glues to connect.This text discussed PTEN structure, function and its correlationses, the PTEN is in tumor repress function mechanism.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1μg /Test)
ICC(1:100)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
本產(chǎn)品僅供科研使用。不能用于人和動物治療等其它臨床診斷使用！
關鍵字： PTEN(Phospho-Ser380/;PTEN 1;PTEN1;Phospho-PTEN (Ser380;磷酸化腫瘤抑制基因PTEN抗體;
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