產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號 | 型號 |
Citrinin | 1mg 5mg 10mg | 518-75-2 | EY-Y0165472 |
Cas No.518-75-2
別名 NSC 186
化學名 (3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
分子式 C13H14O5
分子量 250.3
溶解度 ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Citrinin is a mycotoxin originally isolated from P. citrinum that is also produced by a variety of other fungi that are found as contaminants in human foodstuffs and animal feeds.
In vitro: Previous study found that exposure of HEK293 cells to citrinin led to an arrest of cell cycle G2/M in a concentration-dependent increase. Citrinin treatment could also elevate the expression levels of p53 and p21 proteins, yet attenuate the signals of phosphorylated cell division cycle 2. Moreover, treating HEK293 with citrinin could increase both the value of mitotic index and the population of cells, indicating that arrest of citrinin -induced cell cycle occurred mainly during the mitotic phase [1].
In vivo: Previous study showed that citrinin acted as a nephrotoxin in all tested animal species, but its acute toxicity varied in different species. The 50% lethal dose for ducks is 57 mg/kg; for chickens it is 95 mg/kg; and for rabbits it is 134 mg/kg. In murine kidneys, citrinin could also synergistically act with ochratoxin A to depress RNA synthesis [2].
Clinical trial: Up to now, there is no clinical data reported.
References:
[1] Chang CH, Yu FY, Wu TS, Wang LT, Liu BH. Mycotoxin citrinin induced cell cycle G2/M arrest and numerical chromosomal aberration associated with disruption of microtubule formation in human cells. Toxicol Sci. 2011 Jan;119(1):84-92.
[2] J. W. Bennett and M. Klich. Mycotoxins. Clin.Microbiol.Rev. 16(3), 497-516 (2003).
關鍵字： 518-75-2;C13H14O5;Citrinin;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學、分子生物學和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè)，公司自成立以來，秉承""全心全意服務于科研工作者""的企業(yè)理念，立足生物科技領域，運用生物技術和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機構、高等院校、科研院所、企事業(yè)單位提供優(yōu)質的產(chǎn)品，服務生物科技領域的科學研究人員。
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