產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號 | 型號 |
Artemisinin-d3 | 1 mg | 176652-07-6 | EY-Y0165186 |
Cas No.176652-07-6
別名 N/A
化學(xué)名 N/A
分子式 C15H19D3O5
分子量 285.4
溶解度 DMSO: Slightly soluble,Methanol: Slightly soluble
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity.1,2 It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg.1,3 It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).4 Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner.2 It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.
1.Akoachere, M., Buchholz, K., Fischer, E., et al.In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisininsAntimicrob. Agents Chemother.49(11)4592-4597(2005) 2.Zhu, S., Liu, W., Ke, X., et al.Artemisinin reduces cell proliferation and induces apoptosis in neuroblastomaOncol. Rep.32(3)1094-1100(2014) 3.Robert, A., Benoit-Vical, F., Claparols, C., et al.The antimalarial drug artemisinin alkylates heme in infected miceProc. Natl. Acad. Sci. U.S.A.102(38)13676-13680(2005) 4.Chawira, A.N., Warhurst, D.C., Robinson, B.L., et al.The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in miceTrans. R. Soc. Trop. Med. Hyg.81(4)554-558(1987)
關(guān)鍵字： 176652-07-6;C15H19D3O5;Artemisinin-d3;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè)，公司自成立以來，秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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