別名
N-(3-氨基丙基)-2-[(3-甲基苯基)甲氧基]-N-(2-噻吩基甲基)-苯甲酰胺鹽酸鹽(1:1) 單鹽酸半乙醇半水合物
應(yīng)用
AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.
生化/生理作用
AMTB是一種TRPM8選擇性拮抗劑,與TRPV1或4沒有交叉反應(yīng)性。 icilin激活TRPM8的pIC50為6.23靜脈注射給藥AMTB,可以減少容量負(fù)荷膀胱的節(jié)律性收縮頻率,并抑制血壓和對(duì)膀胱擴(kuò)張的內(nèi)臟運(yùn)動(dòng)反射反應(yīng)。 AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.
Sigma-Aldrich西格瑪奧德里奇(上海)貿(mào)易有限公司
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