產(chǎn)品屬性：

Cas No.1884269-07-1

別名 N/A

化學名 N/A

分子式 C24H25D4NO5

分子量 415.5

溶解度 Chloroform: Slightly Soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble

儲存條件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
AHU377-d4 is intended for use as an internal standard for the quantification of AHU377 by GC- or LC-MS. AHU377 is a methyl ester prodrug form of the neprilysin inhibitor LBQ657 .1 It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.

1.Ksander, G.M., Ghai, R.D., deJesus, R., et al.Dicarboxylic acid dipeptide neutral endopeptidase inhibitorsJ. Med. Chem.38(10)1689-1700(1995)