中文名稱(chēng)

【CYP2D6】重組人細(xì)胞色素P450 2D6

英文名字

Recombinant Human Cytochrome P450 2D6

供應(yīng)商

ProSpec

產(chǎn)品貨號(hào)

ENZ-316

背景資料

Cytochrome P450 2D6 is a member of a complex family of microsomal enzymes（mono-oxygenases) present in the endoplasmic reticulum membrane， which perform detoxification reaction on xenobiotic compounds. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1"（LKM 1) which has been classically defined by immunofluorescence microscopy. The presence of these autoantibodies is considered indicative of Autoimmune Hepatitis Type 2； LKM 1 antibodies have also been detected in patients with hepatitis C viral infection. The International Autoimmune Hepatitis Group therefore has subdivided the AIH type 2 into two subgroups: 2a with HCV and 2b without HCV. AIH 2a patients are often over 40 and predominantly male.
The use of a purified recombinant Cytochrome P450 2D6 antigen allows the differentiation of autoimmune hepatitis from drug-induced hepatitis where transient autoantibodies to other P450 family members occur which cannot be differentiated by immunofluorescence techniques.

序列

該【CYP2D6】重組人細(xì)胞色素P450 2D6Recombinant Human Cytochrome P450 2D6是Prospec品牌 產(chǎn)品，具體的蛋白序列可查看提供的英文版本產(chǎn)品說(shuō)明書(shū)。

來(lái)源宿主

桿狀病毒-昆蟲(chóng)Sf9細(xì)胞中重組表達(dá)

溶解建議

提供的人細(xì)胞色素P450 2D6（CYP2D6）產(chǎn)品為過(guò)濾滅菌的溶液形式；其中人細(xì)胞色素P450 2D6（CYP2D6）產(chǎn)品溶解于50mM 磷酸鉀緩沖液（pH 7.5）， 15%甘油，1mM DTT，1%聚乙二醇辛基苯基醚溶液中.

保存建議

人細(xì)胞色素P450 2D6（CYP2D6）溶液可以在4℃冷藏保存2-4周；如果想延長(zhǎng)保存時(shí)間，建議分裝后置于-20℃凍存.請(qǐng)避免反復(fù)凍融.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專(zhuān)注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類(lèi)公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白?？紤]到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。