中文名稱

【B2M】人β2微球蛋白

英文名字

Human Beta 2 Microglobulin

供應(yīng)商

ProSpec

產(chǎn)品貨號(hào)

PRO-553

背景資料

?2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. ?2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of ?2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I.
Beta 2-microglobulin is present in small amounts in serum， csf， and urine of normal people， and to a much greater degree in the urine and plasma of patients with tubular proteinaemia， renal failure， or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased （e.g. in AIDS， malignant monoclonal plasma cell dyscrasia， solid tumors and autoimmune disease） or because of impaired renal filtration （e.g. due to renal insufficiency， graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy）. Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis， it can aggregate into amyloid fibers that deposit in joint spaces.

序列

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來(lái)源宿主

患有腎小管性蛋白尿病患者的尿液中提取純化

溶解建議

Sterile Filtered White lyophilized （freeze-dried） powder. Lyophilized from 0.02M NH4HCO3. It is recommended to reconstitute the lyophilized HuB2M in phosphate buffer pH > 7.0 containing 0.15M NaCl.

保存建議

Human B2M although stable at room temperature for 3 weeks， should be stored between 2-8℃.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類(lèi)公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。