中文名稱

N-（4-丁基-2-甲基苯基）-N'-羥基甲基亞氨基酰胺； N-羥基-N'-（4-正丁基-2-甲基苯基）甲idine； HET0016

英文名字

N-（4-butyl-2-methylphenyl）-N’-hydroxy-methanimidamide； N-hydroxy-N’-（4-n-butyl-2-methylphenyl）Formamidine； HET0016

供應(yīng)商

開曼生物

產(chǎn)品貨號

75780-10

背景資料

20-HETE is a major biologically active cytochrome P450 （CYP450） metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM， selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9， CYP2D6， and CYP3A4， enzymes important in drug metabolism， significantly less effectively with IC50s in the uM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids （EETs） formation are 2.3 and 2.8 uM， respectively.

產(chǎn)品描述

20-HETE is a major biologically active CYP450 metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation.{12466，12470，12468，12467，9023} HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM， selectively inhibiting CYP4A and 4F isoforms.{8946，12469} HET0016 inhibits CYP2C9， CYP2D6， and CYP3A4， enzymes important in drug metabolism， significantly less effectively with IC50 values in the uM range. The IC50 values for inhibition of COX and epoxyeicosatrienoic acids （EETs） formation are 2.3 and 2.8 uM， respectively.{8946}

保存建議

建議您在收到開曼生物品牌的HET0016 （10 mg）產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

開曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.