中文名稱

17β-雌二醇17-（β-D-葡糖醛酸）|17β-雌二醇17-（β-D-葡糖醛酸）| E217G |β-雌二醇17-（β-D-葡糖醛酸）；（17β）-3-羥基estra-1,3,5（10）-三烯-17-基β-D-吡喃葡萄糖苷神經(jīng)醛酸，單鈉鹽

英文名字

17β-Estradiol 17-(β-D-glucuronide)|17β-Oestradiol 17-(β-D-glucuronide)|E217G|β-Estradiol 17-(β-D-glucuronide); (17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl β-D-glucopyranosiduronic acid, monosodium salt

供應(yīng)商

開(kāi)曼生物

產(chǎn)品貨號(hào)

16156-10

背景資料

Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.{26342} It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km = 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.{26342,26341} In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transport via MRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) (E23G; Item No. 16155).{26341,26340} E217G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.{26341}

產(chǎn)品描述

An estrogen metabolite that acts as a substrate of MRP2 (Km = 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow

保存建議

建議您在收到開(kāi)曼生物品牌的Estradiol 17-(β-D-glucuronide) (sodium salt) (10 mg)產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

開(kāi)曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開(kāi)曼生物可提供用于檢測(cè)的特色試劑盒，如：類(lèi)花生酸類(lèi)物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類(lèi)花生酸類(lèi)物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體