中文名稱

葡萄糖基鞘氨醇，植物

英文名字

Glucosylsphingosine, plant

供應(yīng)商

Matreya

產(chǎn)品貨號

1310-5

背景資料

Glucosylsphingosine is the lyso-derivative of the common glycolipid glucocerebroside. Gaucher disease is characterized by an accumulation of glucocerebroside due to a deficiency in the enzyme glucocerebrosidase and it has now been found that glucopsychosine also accumulates in this disease.1 This accumulation of glucosylsphingosine contributes to neuronal dysfunction and destruction in patients with neuronopathic Gaucher disease2 and it has been found to be a potent inhibitor of glucocerebrosidase. At least some instances of Gaucher disease also have a deficiency in the activity of glucosylsphingosine beta-glucosidase, the enzyme responsible for cleaving off the glucose of glucopsychosine and glucocerebroside. Like glucocerebroside and galactocerebroside, glucosylsphingosine can increase Ca2 + mobilization from intracellular stores although it uses a different mechanism.3 Conduritol B epoxide (CBE), an inhibitor of beta-glucosidase, and l-phenyl-2- decanoylamino-3-morpholino-l-propanol (PDMP), an inhibitor of glucosylceramide synthase, can be used to create a model of Gaucher disease and consequently an accumulation of glucosylsphingosine.4

產(chǎn)品描述

lyso-Glucocerebroside|1-beta-D-Glucosylsphingadienine|Glucopsychosine

產(chǎn)品形式

該葡萄糖基鞘氨醇，植物產(chǎn)品為固體形式

保存建議

對于本產(chǎn)品，我們推薦使用-20℃藍冰低溫進行運輸。在您收到貨物后，我們建議在-20℃溫度下冷凍保存，溶解使用說明請參考本品說明書。

其他