Name: IL-4 Inhibitor
CAS#: 1332184-63-0
Chemical Formula: C18H12FN3O2
Exact Mass: 321.0914
Molecular Weight: 321.3114
Elemental Analysis: C, 67.29; H, 3.76; F, 5.91; N, 13.08; O, 9.96
Description: IL-4 inhibitor is an inhibitor of IL-4. It binds to IL-4 with a Kd value of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay. It is selective for IL-4 over IL-13. IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes, indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
IUPAC/Chemical Name: 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile
InChi Key: DWZPPBGRCDPFSS-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H12FN3O2/c19-12-4-1-10(2-5-12)15-8-13(14(9-20)18(21)22-15)11-3-6-16(23)17(24)7-11/h1-8,23-24H,(H2,21,22)
SMILES Code: N#CC1=C(N=C(C=C1C2=CC(O)=C(C=C2)O)C3=CC=C(C=C3)F)N
Appearance: Solid powder
關(guān)鍵字： 1332184-63-0;IL-4 Inhibitor;
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