Name: Loxapine-d8
CAS#: 1189455-63-7
Chemical Formula: C18H10D8ClN3O
Exact Mass: 335.1641
Molecular Weight: 335.8608
Elemental Analysis: C, 64.37; H, 7.80; Cl, 10.55; N, 12.51; O, 4.76
Description: Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine by GC- or LC-MS. Loxapine is an atypical antipsychotic. It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to α1A-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.
IUPAC/Chemical Name: 2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine
InChi Key: XJGVXQDUIWGIRW-JNJBWJDISA-N
InChi Code: InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3/i8D2,9D2,10D2,11D2
SMILES Code: ClC1=CC2=C(OC3=C(N=C2N4C([2H])(C([2H])(N(C([2H])(C4([2H])[2H])[2H])C)[2H])[2H])C=CC=C3)C=C1
Appearance: Solid powder
關鍵字： 1189455-63-7;Loxapine-d8;
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