AdministrationofWAY-200070(30mg/kgs.c.)causesnucleartranslocationofERRβreceptorsinWTmice.AdministrationofWAY-200070(30mg/kgs.c.)producesadelayed50%increaseindopamineinthestriatumofwildtypemice.WAY-200070(30mg/kgs.c.)reducesimmobilitytimeinthemousetailsuspensiontestindicatinganantidepressant-likeeffect.IngonadallyintactmaleandfemalemiceWAY-200070increasesagonisticbehaviorssuchaspushingdownandaggressivegrooming,whileleavingattacksunaffected.Ovariectomized(ovx)micetreatedwithPPTfailtolearnthesociallyacquiredpreference,whileWAY-200070-treatedovxmiceshowsatwo-foldprolongedpreferenceforthefoodeatenbytheirdemonstrator.WAY-200070,showssignificantlydecreasedanxiety-likebehaviorsinboththeopen-fieldandelevatedplusmazeandsignificantlylessdepressive-likebehaviorsintheforcedswimtest.
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