中文名稱

5-（4-氯苯基）-1-（4-甲氧基苯基）-3-（三氟甲基）-1H-吡唑； SC-560

英文名字

5-（4-chlorophenyl）-1-（4-methoxyphenyl）-3-（trifluoromethyl）-1H-pyrazole； SC-560

供應(yīng)商

開曼生物

產(chǎn)品貨號

70340-1

產(chǎn)品報價

￥231/1mg

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

SC-560 is a member of the diaryl heterocycle class of cyclooxygenase （COX） inhibitors which includes celecoxib （Celebrex?） and rofecoxib （Vioxx?）. However， unlike these selective COX-2 inhibitors， SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes， the IC50 value for SC-560 with respect to COX-1 is 9 nM， while the corresponding IC50 value for COX-2 is 6.3 uM. Thus， SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat， where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However， SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model， in which the COX-2 generated prostaglandins play a significant role in the inflammatory process. In whole cells， however， SC-560 appears to act as a non-selective COX inhibitor. The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.

產(chǎn)品描述

SC-560 is a member of the diaryl heterocycle class of COX inhibitors which includes celecoxib （Celebrex?） and rofecoxib （Vioxx?）. However， unlike these selective COX-2 inhibitors， SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes， the IC50 value for SC-560 with respect to COX-1 is 9 nM， while the corresponding IC50 value for COX-2 is 6.3 uM.{7675} Thus， SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat， where 10 mg/kg completely abolishes the ionophore-induced production of TXB2 in whole blood. However， SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model， in which the COX-2 generated prostaglandins play a significant role in the inflammatory process.{1282} In whole cells， however， SC-560 appears to act as a non-selective COX inhibitor.{14472} The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.

保存建議

建議您在收到開曼生物品牌的SC-560 （1 mg）產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

開曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產(chǎn)品以及客戶訂制化服務(wù).