中文名稱

（5Z）-7-氧玉米醇

英文名字

(5Z)-7-Oxo Zeaenol

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開(kāi)曼生物

產(chǎn)品貨號(hào)

17459-1

產(chǎn)品報(bào)價(jià)

￥1425.6/1mg

產(chǎn)品說(shuō)明書(shū)

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產(chǎn)品新聞

背景資料

Transforming growth factor-β-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that activates JNK/p38 and NF-κB pro-inflammatory signaling pathways. (5Z)-7-Oxo zeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein) without significantly affecting the kinase activities of other MAPKKK family members (IC50 = 411 nM for MEK1).{28252} In cells, (5Z)-7-oxo zeaenol is reported to irreversibly block IL-1-induced activation of TAK1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM.{28252} (5Z)-7-Oxo zeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation.{28252} This compound has been found to sensitize cells to TRAIL- and TNF-α-induced apoptosis in vitro.{28253}

產(chǎn)品描述

A natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein, TAB1); irreversibly blocks IL-1-induced activation of TAK1, NF-κB, and JNK/p38 (IC50s = 65-83 nM) and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro

保存建議

建議您在收到開(kāi)曼生物品牌的L-783,279; FR148083; LL-Z 1640-2 (CAS 253863-19-3) (1 mg)產(chǎn)品后置于-20℃保存.

其他

開(kāi)曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開(kāi)曼生物可提供用于檢測(cè)的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為開(kāi)曼生物在中國(guó)的區(qū)域總代理，艾美捷科技有限公司將為中國(guó)客戶提供最全面的開(kāi)曼生物產(chǎn)品以及客戶訂制化服務(wù).