中文名稱

【鐵蛋白】人肝鐵蛋白

英文名字

Human Liver Ferritin

供應(yīng)商

ProSpec

產(chǎn)品貨號(hào)

PRO-564

產(chǎn)品報(bào)價(jià)

￥1610/200ug   ￥6440/1mg   ￥39100/10mg

產(chǎn)品說明書

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產(chǎn)品新聞

背景資料

Ferritin is the main intracellular iron storage protein in prokaryotes and eukaryotes. Ferritin’s major functions are the storage of iron in a soluble and nontoxic state and its release in a controlled fashion. An iron-containing protein complex is found mostly in the intestinal mucosa， spleen， and liver. Ferritin is composed of 24 subunits of the heavy and light chains. Variation in ferritin subunit composition may influence the rates of iron uptake and release in different tissues. Defects in the light chain ferritin gene are linked to a number of neurodegenerative diseases and hyperferritinemia-cataract syndrome. The genes that encode the light and heavy chains are on located different chromosomes. The light chain genes are in chromosome region 19q13.3-q13.4 whilst those for the heavy chain are in chromosome region 11q12-q13. Ferritin is shaped like a hollow sphere， inside which the iron is stored in the Fe（III） oxidation state. The iron is integrated in the mineral ferrihydrite， [FeO（OH）]8[FeO（H2PO4）]， which is attached to the inner wall of the sphere. To release iron once the body needs it， the iron must be altered from the Fe（III） to the Fe（II） oxidation state. Subsequently， the iron leaves through channels in the spherical structure. Therefore， the structure of ferritin is tremendously important for the protein’s ability to store and release iron in a controlled mode.
The amount of ferritin in the blood （serum ferritin level） is directly related to the amount of iron stored in the body. The body has a "buffer" against iron deficiency （if the blood has too little iron， ferritin can release more） and， to a lesser extent， iron overload （if the blood and tissues of the body have too much iron， ferritin can help store the excess iron）.

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來源宿主

人肝臟組織中提取純化

溶解建議

Sterile Filtered brownish solution. The protein solution is in 0.05M TRIS buffer pH 7.5 containing 1.0M NaCl and 0.09% NaN3.

保存建議

Human Ferritin should be stored at 2-8℃.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。