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EGCG ((-)-Epigallocatechin Gallate)

中文名稱(chēng)：(-)-表沒(méi)食子兒茶素沒(méi)食子酸酯

EGCG ((-)-Epigallocatechin Gallate)是從綠茶中分離的一種有效的抗氧化劑Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滯EGF受體和HER-2受體的激活，抑制脂肪酸合成酶以及谷氨酸脫氫酶的活性。

EGCG ((-)-Epigallocatechin Gallate) Chemical Structure

EGCG ((-)-Epigallocatechin Gallate) Chemical Structure

CAS: 989-51-5

規(guī)格 價(jià)格 庫(kù)存 購(gòu)買(mǎi)數(shù)量
10mM (1mL in DMSO) 790 現(xiàn)貨
50mg 647.01 現(xiàn)貨
1g 3251.43 現(xiàn)貨
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EGCG ((-)-Epigallocatechin Gallate)相關(guān)產(chǎn)品

相關(guān)信號(hào)通路圖

Telomerase Signaling Pathways

Telomerase信號(hào)通路圖

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類(lèi)型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
human MDA435/LCC6MDR cells Function assay 10 μM 5 days Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for paclitaxel at 10 uM after 5 days by CellTiter 96 Aqueous assay, IC50=0.1226 μM 25985195
human Caco-2 cells Growth inhibition assay 25 μM 6 days Growth inhibition of human Caco-2 cells at 25 uM after 6 days 18324763
mouse 3T3 cells Function assay 1-20 μM 12 h Antimigratory activity against Swiss albino mouse 3T3 cells assessed as increase of cell numbers at 1 to 20 uM after 12 hrs by by scratch-wound assay 21080642
human Jurkat cells Function assay 10-55 μM 24 h Inhibition of TNFalpha-induced NF-kappaB activation in human Jurkat cells at 10 to 55 uM after 24 hrs by electrophoretic mobility shift assay 21080642
human Raji cells Growth inhibition assay 10 μM 48 h Growth inhibition against human Raji cells assessed as cell viability at 10 uM after 48 hrs by trypan blue based microscopic analysis in presence of superoxide dismutase 21434603
human PC3 cells Proliferation assay 10-100 μM 48 h Antiproliferative activity against human PC3 cells at 10 to 100 uM after 48 hrs by hemocytometric cell counting method 23867167
human A431 cells Function assay 100 μM 12 h Reduction of clustering of GFP-GPI in lipid rafts of human A431 cells at 100 uM after 12 hrs by confocal microscopic analysis 24456004
human SKBR3 cells Function assay 200μM 30 mins Downregulation of ErbB2 protein expression in human SKBR3 cells in serum free medium at 200 uM after 30 mins by immunofluorescence staining-based confocal microscopic analysis 24456004
human 293T cells Function assay 50 μM 12 h Inhibition of DYRK1A in human 293T cells assessed as reduction of GLI1 transcription activity at 50 uM after 12 hrs by dual-luciferase reporter gene assay 22154664
CHO cells Cytotoxic?assay 48 h Cytotoxicity against CHO cells expressing OATP1B3 haplotype 1 after 48 hrs by fluorescence based CellTiter-Glo assay, IC50=3.2 μM 23327877
MDCK cells Function assay 4 days Antiviral activity against influenza A virus (A/swine/OH/511445/2007(H1N1)) Oh7 infected in MDCK cells assessed as inhibition of viral replication after 4 days by quantitative RT-PCR, ED50=8.3 μM 22115591
human HL60 cells Proliferation assay 3 days Antiproliferative activity against human HL60 cells after 3 days, IC50=9.4 μM 18693020
HSC-T6 cells? Function assay 48 h Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay, IC50=9.9 μM 21504848
mouse RAW264.7 cells Function assay 5 days Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as decrease in TRAP-positive multi-nucleated cells after 5 days, IC50=29.8 μM 21456521
human A431 cells Proliferation assay 48 h Antiproliferative activity against human A431 cells overexpressing ErbB in serum-free medium assessed as cell viability after 48 hrs by WST-1 assay, EC50=38 μM 24456004
human MDA-MB-231 cells Proliferation assay 24 h Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay 22459208
human HepG2 cells Function assay 24 h Inhibition of oleic acid-induced triglyceride over-accumulation in human HepG2 cells incubated for 24 hrs relative to untreated control 21824690
human HepG2 cells Function assay 24 h Antioxidant activity in human HepG2 cells assessed as reduction of oleic acid-induced ROS generation incubated for 24 hrs by DHCF-DA based fluorimetric assay relative to untreated control 21824690
human MDA-MB-231 cells Proliferation assay 24 h Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay 22459208
human K562 cells Function assay 24 h Induction of 67 kDa laminin receptor expression in human K562 cells after 24 hrs by flow cytometry analysis 21434603
human HL60 cells Function assay 24 h Induction of 67 kDa laminin receptor expression in human HL60 cells after 24 hrs by flow cytometry analysis 21434603
SH-SY5Y cells Function assay Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release, EC50=0.03987 μM 19138859
Sf9 cells Function assay Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintillation counting method, IC50=0.5 μM 25406944
human U937 cells Function assay Inhibition of telomerase in human U937 cells, IC50=1 μM 22413845
human HeLa cells Function assay Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction followed by compound washout by spin-telomeric repeat amplification protocol, IC50=1.08 μM 22413845
mouse 3T3-L1 cells Function assay Inhibition of G6PD-mediated NADPH production in mouse 3T3-L1 cells, IC50=25 μM 18313308
HSC-T6 cells Proliferation assay Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability, IC50=29.8 μM 25322455
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生物活性

產(chǎn)品描述 EGCG ((-)-Epigallocatechin Gallate)是從綠茶中分離的一種有效的抗氧化劑Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滯EGF受體和HER-2受體的激活，抑制脂肪酸合成酶以及谷氨酸脫氫酶的活性。
靶點(diǎn)
telomerase [4] DNMT [4] HER2 [5] EGFR [5] FASN [6]
體外研究(In Vitro)
體外研究活性

(-)-Epigallocatechin gallate在健康細(xì)胞中具有強(qiáng)效抗氧化作用，并降低氧化損傷，作為抗血管生成和抗腫瘤劑，也是腫瘤細(xì)胞對(duì)化療應(yīng)答的調(diào)節(jié)劑。(-)-Epigallocatechin gallate具有多種抗腫瘤作用，例如抗增殖，抗血管新生，阻斷各種癌細(xì)胞轉(zhuǎn)化，細(xì)胞周期阻滯和抑制腫瘤轉(zhuǎn)移。(-)-Epigallocatechin gallate通過(guò)調(diào)節(jié)多個(gè)腫瘤相關(guān)的細(xì)胞信號(hào)通路（調(diào)節(jié)關(guān)鍵信號(hào)蛋白的表達(dá)水平，例如核因子-κB, MAPKs和激活蛋白-1，EGFR，IGF，COX-2）影響腫瘤基因的甲基化和配體與膜受體結(jié)合發(fā)揮抗腫瘤效果。[1] (-)-Epigallocatechin gallate具有免疫調(diào)節(jié)作用。多種類(lèi)型的免疫細(xì)胞在先天的和適應(yīng)性免疫系統(tǒng)中都會(huì)不同程度受到(-)-Epigallocatechin gallate的影響。在這些作用中，對(duì)T細(xì)胞的顯著作用被反復(fù)證明，包括T細(xì)胞激活，增殖，分化和細(xì)胞因子產(chǎn)生?；诨加凶陨砻庖呒膊〉膭?dòng)物模型的研究報(bào)道表明，綠茶/EGCG處理會(huì)使動(dòng)物的病情好轉(zhuǎn)。[2] (-)-Epigallocatechin gallate具有抗感染活性。(-)-Epigallocatechin gallate的以不同激活模式產(chǎn)生的抗病毒活性在很多種屬的病毒中被證實(shí)，例如逆轉(zhuǎn)錄病毒，正粘病毒科和黃病毒科，還包括重要的人類(lèi)病原細(xì)菌，如人類(lèi)免疫缺陷病原體，甲型流感病毒和丙型肝炎病毒。[3]
實(shí)驗(yàn)圖片 檢測(cè)方法 檢測(cè)指標(biāo) 實(shí)驗(yàn)圖片 PMID
Western blot β-catenin / p-AKT / Cyclin D1 p-MAPK / MAPK Notch1 / Notch2 28693189
Growth inhibiton assay Cell proliferation Cell viability 23525843
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05758571 Recruiting
Interstitial Pneumonia|Neoplasms Malignant
Shandong Cancer Hospital and Institute
 January 5 2023 Phase 1|Phase 2

化學(xué)信息&溶解度

分子量 458.37 分子式

C22H18O11
CAS號(hào) 989-51-5 SDF Download EGCG ((-)-Epigallocatechin Gallate) SDF
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

DMSO : 92 mg/mL ( (200.71 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開(kāi)封DMSO)

Ethanol : 92 mg/mL (200.71 mM)

Water : 20 mg/mL (43.63 mM)

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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