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Acetylcysteine (N-acetylcysteine)
僅限科研使用
Acetylcysteine (N-acetylcysteine)
別名: N-acetylcysteine 中文名稱：乙酰半胱氨酸
Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine)是ROS抑制劑，拮抗多種蛋白酶體抑制劑的活性。它還是腫瘤壞死因子TNF的抑制劑，主要用作祛痰劑，可通過維持或恢復肝臟中谷胱甘肽的濃度來處理撲熱息痛(對乙酰氨基酚過量)。Acetylcysteine(N-acetyl-l-cysteine) 通過抑制IκB kinases抑制TNF誘導的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通過線粒體依賴性途徑誘導凋亡并抑制鐵死亡和病毒復制。在溶液中不穩(wěn)定，請現(xiàn)配現(xiàn)用！
Acetylcysteine (N-acetylcysteine) Chemical Structure
CAS: 616-91-1
產(chǎn)品質控
批次：
純度：
99.97%
99.97
常與Acetylcysteine (N-acetylcysteine)一起在實驗中被使用的化合物
Acetylcysteine和Ciprofloxacin療法被用作部分膽道梗阻的替代治療選擇。
Acetylcysteine和Tigecycline顯著減少所有活的生物膜相關細菌。
Aslam S, et al. Antimicrob Agents Chemother. 2007 Apr; 51(4): 1556–1558.
Acetylcysteine和Prostaglandin E2協(xié)同減少細胞凋亡，改善肝酶，預防死亡。
North TE, et al. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17315-20.
Acetylcysteine和Colistin在體外表現(xiàn)出協(xié)同作用Stenotrophomonas maltophilia。
Acetylcysteine (N-acetylcysteine)相關產(chǎn)品
| 相關靶點 | TNF-α | 點擊展開 |
|---|---|---|
| 相關產(chǎn)品 | R-7050 Cepharanthine Bioymifi Geraniin CPI-1189 | 點擊展開 |
| 相關化合物庫 | 自噬化合物庫 凋亡分子化合物庫 鐵死亡化合物庫 細胞焦亡化合物庫 線粒體靶向化合物庫 | 點擊展開 |
相關信號通路圖
細胞實驗數(shù)據(jù)示例
| 細胞系 | 實驗類型 | 給藥濃度 | 孵育時間 | 活性描述 | 文獻信息 |
|---|---|---|---|---|---|
| HUVEC cells | Function assay | 2μM,4μM,8μM | 90min | HUVECs that were exposed with serum of P. falciparum and treated with NAC 2 μM，4 μM，8 μM. Supernatant from culture and lysed cells culture were measured for H2O2, GSH and MDA levels. | 21602763 |
| HUVEC cells | Function assay | 10μM | 2h | HUVECs were pretreated with 10 μM NAC for 2 hours, and then treated with 0.5 μM PCB 118. presentce of NAC for 48 hours. | 28592194 |
| NHBE | Cytotoxicity assay | 1 mM | 18 hrs | Cytoprotective activity in NHBE cells assessed as inhibition of tBHP-induced GSH depletion at 1 mM preincubated for 18 hrs followed by tBHP addition for 4 hrs by thiostar dye based fluorescence assay | 27031670 |
| HUVEC | Antioxidant assay | 5 mmol/L | 4 hrs | Antioxidant activity against H2O2-induced lipid accumulation in HUVEC cells assessed as reduction in MDA level at 5 mmol/L incubated 4 hrs prior to H2O2 challenge measured after 12 hrs | 22841280 |
| HUVEC | Antioxidant assay | 5 mmol/L | 4 hrs | Antioxidant activity in HUVEC cells assessed as reduction in H2O2-induced GSH activity at 5 mmol/L incubated 4 hrs prior to H2O2 challenge measured after 12 hrs | 22841280 |
| HUVEC | Cytotoxicity assay | 5 mmol/L | 4 hrs | Inhibition of H2O2-induced cytotoxicity in HUVEC cells assessed as cell viability at 5 mmol/L incubated 4 hrs prior to H2O2 challenge measured after 12 hrs by MTT assay | 22841280 |
| HUVEC | Cytotoxicity assay | 5 mmol/L | 4 hrs | Inhibition of H2O2-induced cytotoxicity in HUVEC cells assessed as LDH release at 5 mmol/L incubated 4 hrs prior to H2O2 challenge measured after 12 hrs by LDH assay | 22841280 |
| SH-SY5Y | Neuroprotective assay | 5 mM | 4 hrs | Neuroprotective activity in H2O2-stimulated human SH-SY5Y cells assessed as upregulation of Bax expression at 5 mM incubated for 4 hrs prior to H2O2 challenge measured after 12 hrs by Western blotting analysis | 23403085 |
| SH-SY5Y | Neuroprotective assay | 5 mM | 4 hrs | Neuroprotective activity in H2O2-stimulated human SH-SY5Y cells assessed as downregulation of Bcl2 expression at 5 mM incubated for 4 hrs prior to H2O2 challenge measured after 12 hrs by Western blotting analysis | 23403085 |
| HT22 | Neuroprotective assay | 5 mM | 24 hrs | Neuroprotective activity against glutamate-induced cell death in mouse HT22 cells assessed as increase in cell viability at 5 mM after 24 hrs by MTT assay | 29122481 |
| HT22 | Neuroprotective assay | 50 uM | 10 to 12 hrs | Neuroprotective activity against glutamate-induced cell death in mouse HT22 cells assessed as reduction in apoptotic cells at 50 uM after 10 to 12 hrs by Annexin V-alexa 488/propidium iodide staining based flow cytometry | 29122481 |
| HL-7702 | Hepatoprotective assay | 10 uM | 24 hrs | Hepatoprotective activity against APAP-induced cell injury in human HL-7702 cells assessed as increase in survival rate at 10 uM pre-incubated for 24 hrs before APAP addition and measured 6 hrs post APAP challenge by MTT assay | 28729056 |
| PC12 | Cytotoxicity assay | 24 hrs | Inhibition of 6-hydroxydopamine induced cytotoxicity in rat PC12 cells pretreated for 24 hrs assessed as elevation of intracellular glutathione level | 17158454 | |
| BL21 (DE3) | Function assay | 30 mins | Inhibition of hexahistidine-tagged IMP-7 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using fluorocillin as substrate incubated for 30 mins by TECAN fluorescent plate reader analysis, IC50 = 20.7 μM. | 25815530 | |
| PC12 | Cytotoxicity assay | 24 hrs | Inhibition of hydrogen peroxide induced cytotoxicity in rat PC12 cells pretreated for 24 hrs assessed as elevation of intracellular glutathione level | 17158454 | |
| 點擊查看更多細胞系數(shù)據(jù) | |||||
生物活性
| 產(chǎn)品描述 | Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine)是ROS抑制劑，拮抗多種蛋白酶體抑制劑的活性。它還是腫瘤壞死因子TNF的抑制劑，主要用作祛痰劑，可通過維持或恢復肝臟中谷胱甘肽的濃度來處理撲熱息痛(對乙酰氨基酚過量)。Acetylcysteine(N-acetyl-l-cysteine) 通過抑制IκB kinases抑制TNF誘導的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通過線粒體依賴性途徑誘導凋亡并抑制鐵死亡和病毒復制。在溶液中不穩(wěn)定，請現(xiàn)配現(xiàn)用！ | ||||
|---|---|---|---|---|---|
| 靶點 |
|
| 體外研究(In Vitro) | ||||
| 體外研究活性 | N-acetylcysteine抑制c-Jun N末端激酶，P38 MAP激酶和氧化還原敏感激活蛋白1和核因子κB轉錄因子的活化，調節(jié)多種基因的表達。 N-acetylcysteine也能阻止細胞凋亡并通過激活細胞外信號調節(jié)激酶通路，是用于治療某些退行性疾病有用的一個概念。N-acetylcysteine通過其還原活性直接調節(jié)幾種蛋白質的活性。[1] 在沒有其它營養(yǎng)支持的血清剝奪PC12細胞中，N-acetylcysteine可以防止細胞凋亡的DNA片段，并保持長期生存。 N-acetylcysteine還可以防止PC12細胞和交感神經(jīng)元死亡。[2] 在大鼠和人的主動脈平滑肌細胞中，N-acetylcysteine劑量依賴性地減少存活率。[3] 在PC12細胞中，N-acetylcysteine激活Ras-外信號調節(jié)激酶（ERK）途徑。N-acetylcysteine保護撤出營養(yǎng)支持誘發(fā)的神經(jīng)元細胞免受死亡。 N-acetylcysteine增加存儲在血管組織中一氧化氮（NO）的釋放。 N-乙酰半胱氨酸預處理的PC12細胞干擾NGF-依賴的信號和神經(jīng)突增生，并且有人提出，N-acetylcysteine干擾氧化還原敏感步驟。 [4] |
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|---|---|---|---|---|
| 體內研究(In Vivo) | ||
| 體內研究活性 | N-acetylcysteine提高了12月齡SAMP8小鼠在T型迷宮電擊回避范式和杠桿記者食欲任務的認知能力，不引起電機活動，激勵非特異性作用以避免震動，或體重。[5] |
|
|---|---|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT04520139 | Not yet recruiting | Ovarian Cancer|Cognitive Impairment |
University of California Irvine|Jarrow Formulas Inc |
December 2024 | Phase 1|Phase 2 |
| NCT06112834 | Not yet recruiting | Botulism |
California Department of Public Health |
June 2024 | Phase 2 |
| NCT06260566 | Not yet recruiting | Biliary Atresia |
Sanjiv Harpavat|Baylor College of Medicine |
May 2024 | Phase 1 |
| NCT06377410 | Not yet recruiting | Chronic Obstructive Pulmonary Disease |
National University of Malaysia |
May 1 2024 | Not Applicable |
| NCT06223568 | Not yet recruiting | Squamous Cell Carcinoma of the Head and Neck|Oropharynx|Human Papillomavirus Viruses|Drug Therapy|Cancer Vaccine |
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
May 15 2024 | Phase 2 |
化學信息&溶解度
| 分子量 | 163.19 | 分子式 | C5H9NO3S |
| CAS號 | 616-91-1 | SDF | Download Acetylcysteine (N-acetylcysteine) SDF |
| Smiles | CC(=O)NC(CS)C(=O)O | ||
| 儲存條件(自收到貨起) | 3年-20°C 粉狀 | 此產(chǎn)品性質不穩(wěn)定，需現(xiàn)配現(xiàn)用!建議您購買分裝規(guī)格，或者在收到貨后進行分裝。 | |
|
體外溶解度 |
DMSO : 32 mg/mL ( (196.09 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO) Water : 32 mg/mL (196.09 mM) Ethanol : 32 mg/mL (196.09 mM) |
摩爾濃度計算器 |
|
體內溶解度 現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑 |
動物體內配方計算器 | ||||
實驗計算
動物體內配方計算器（澄清溶液）
第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）
mg/kg
g
μL
只
第二步：請輸入動物體內配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結果：
工作液濃度： mg/ml；
DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；
體內配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。
體內配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。
注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。
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