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Actinomycin D (Dactinomycin)

別名: Act D, RASP-101 中文名稱：放線菌素D, 更生霉素

此產(chǎn)品請(qǐng)避光密封保存。

Actinomycin D (Dactinomycin, Act D, RASP-101)是一種從鏈霉菌屬的土壤細(xì)菌中分離出來(lái)的重要的多肽抗生素。Actinomycin D (Dactinomycin) 可抑制 DNA repair，并使 cell cycle 停滯在G1期，其IC50值分別為0.42 μM和0.4 nM。Actinomycin D (Dactinomycin) 是 autophagy 的激活劑，可在高危慢性淋巴細(xì)胞性白血病中誘導(dǎo)p53依賴性細(xì)胞的死亡并延長(zhǎng)生存期。此產(chǎn)品為?；罚毙远拘?易燃/皮膚腐蝕），請(qǐng)?jiān)诖┐鞣雷o(hù)面罩、防護(hù)手套和防護(hù)服后使用。 已取得危險(xiǎn)化學(xué)品經(jīng)營(yíng)許可

Actinomycin D (Dactinomycin) Chemical Structure

Actinomycin D (Dactinomycin) Chemical Structure

CAS: 50-76-0

規(guī)格 價(jià)格 庫(kù)存 購(gòu)買數(shù)量
10mg 1613.93 現(xiàn)貨
50mg 4906.57 現(xiàn)貨
100mg 6855.5 現(xiàn)貨
1g 34275.21 現(xiàn)貨
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Actinomycin D (Dactinomycin)相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
NCI-H157 Apoptosis assay 10 uM 5 hrs Induction of apoptosis in human NCI-H157 cells assessed as live cell level at 10 uM incubated for 5 hrs in serum-free medium by annexin V/propidium iodide staining by flow cytometry 22863528
HeLa Cytotoxicity assay 1 uM 18 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell viability at 1 uM after 18 hrs by inverse MTT assay 25028062
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay, EC50 = 0.000201 μM. 27736087
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay, EC50 = 0.000276 μM. 27736087
L1210 Function assay 3 hrs Inhibition of RNA synthesis in mouse L1210 cells assessed as [3H]-uridine incorporation preincubated for 3 hrs before [3H]-uridine addition measured after 1 hr by scintillation spectrometric analysis, ED50 = 0.009 μM. 330857
L1210 Function assay 3 hrs Inhibition of DNA synthesis in mouse L1210 cells assessed as [3H]-thymidine incorporation preincubated for 3 hrs before [3H]-thymidine addition measured after 1 hr by scintillation spectrometric analysis, ED50 = 0.4 μM. 330857
HMO2 Cytotoxicity assay 48 hrs Cytotoxicity against human HMO2 cells after 48 hrs by sulforhodamine assay, GI50 = 0.3 μM. 10757717
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine assay, GI50 = 0.5 μM. 10757717
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by sulforhodamine assay, GI50 = 1 μM. 10757717
P388 Antiproliferative assay 48 hrs Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay, IC50 = 0.0002 μM. 2778449
HT-29 Antiproliferative assay 96 hrs Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay, IC50 = 0.223 μM. 2778449
Jurkat T Function assay 48 hrs Inhibitory concentration was evaluated on human Jurkat T-cells after their exposure for 48 hours, IC50 = 0.0045 μM. 11052798
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells in log-phase after 48 hrs by MTT assay, IC50 = 0.001 μM. 16309323
Vero Cytotoxicity assay 48 hrs Cytotoxicity against african green monkey Vero cells in log-phase after 48 hrs by MTT assay, IC50 = 0.001 μM. 16309323
Hep2 Cytotoxicity assay 48 hrs Cytotoxicity against human Hep2 cells in log-phase after 48 hrs by MTT assay, IC50 = 0.006 μM. 16309323
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells in lag-phase after 48 hrs by MTT assay, IC50 = 0.011 μM. 16309323
Vero Cytotoxicity assay 48 hrs Cytotoxicity against african green monkey Vero cells in lag-phase after 48 hrs by MTT assay, IC50 = 0.071 μM. 16309323
Hep2 Cytotoxicity assay 48 hrs Cytotoxicity against human Hep2 cells in lag-phase after 48 hrs by MTT assay, IC50 = 0.191 μM. 16309323
CCRF-CEM Cytotoxicity assay 72 hrs Cytotoxicity against human CCRF-CEM cells after 72 hrs, IC50 = 0.0016 μM. 18329887
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 0.0004 μM. 18461997
HT29 Antiproliferative assay 48 hrs Antiproliferative activity against human HT29 cells after 48 hrs by MTT assay, IC50 = 0.0029 μM. 18461997
U2OS Antiproliferative assay 48 hrs Antiproliferative activity against human U2OS cells after 48 hrs by MTT assay, IC50 = 0.0032 μM. 18461997
HeLa Function assay 2 hrs Inhibition of transcriptional activity in human HeLa cells assessed as [3H]uridine utilization after 2 hrs by scintillation counting, IC50 = 0.2624 μM. 20118940
HeLa Function assay 2 hrs Inhibition of protein synthesis in human HeLa cells assessed as [35S]cysteine/methionine utilization after 2 hrs by scintillation spectroscopy, IC50 = 0.5197 μM. 20118940
NCI-H460 Cytotoxicity assay 72 hrs Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay, IC50 = 0.008 μM. 20704331
SF268 Cytotoxicity assay 72 hrs Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay, IC50 = 0.016 μM. 20704331
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay, IC50 = 0.103 μM. 20704331
Vero Cytotoxicity assay 20 hrs Cytotoxicity against african green monkey Vero cells after 20 hrs by MTS assay, IC50 = 11 μM. 21093966
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 0.0011 μM. 22705001
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 0.0072 μM. 22705001
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 0.024 μM. 22705001
Vero Cytotoxicity assay 48 hrs Cytotoxicity against african green monkey Vero cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 0.071 μM. 22705001
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells in lag phase of growth after 48 hrs, IC50 = 0.0011 μM. 24709561
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells in log phase of growth after 48 hrs, IC50 = 0.0016 μM. 24709561
Hep2 Cytotoxicity assay 48 hrs Cytotoxicity against human Hep2 cells in log phase of growth after 48 hrs, IC50 = 0.0062 μM. 24709561
Vero Cytotoxicity assay 48 hrs Cytotoxicity against African green monkey Vero cells in log phase of growth after 48 hrs, IC50 = 0.01 μM. 24709561
Vero Cytotoxicity assay 48 hrs Cytotoxicity against African green monkey Vero cells in lag phase of growth after 48 hrs, IC50 = 0.072 μM. 24709561
Hep2 Cytotoxicity assay 48 hrs Cytotoxicity against human Hep2 cells in lag phase of growth after 48 hrs, IC50 = 0.17 μM. 24709561
HEK293 Function assay 30 mins Inhibition of human DDR2 expressed in HEK293 cells assessed as reduction in collagen-1-induced DDR2 tyrosine phosphorylation pre-incubated for 30 mins by immunoblotting method, IC50 = 9 μM. 25569119
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay, IC50 = 0.0011 μM. 28923386
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay, IC50 = 0.0072 μM. 28923386
Vero Cytotoxicity assay 48 hrs Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay, IC50 = 0.011 μM. 28923386
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay, IC50 = 0.024 μM. 28923386
Vero Cytotoxicity assay 48 hrs Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay, IC50 = 0.071 μM. 28923386
A2780 Cytotoxicity assay Cytotoxicity against human A2780 cells, Activity = 0.0017 μM. 16562838
L1210 Function assay Inhibition of RNA synthesis in mouse L1210 cells by [3H]-uridine incorporation assay, ED50 = 0.015 μM. 573799
L1210 Function assay Inhibition of DNA synthesis in mouse L1210 cells by [3H]-thymidine incorporation assay, ED50 = 0.6 μM. 573799
P388 Function assay Concentration required for 50% inhibition of incorporation of labeled uridine by P388 cells for the synthesis of RNA (in vitro), ED50 = 0.046 μM. 6169834
P388 Function assay Concentration required for 50% inhibition of incorporation of labeled thymidine by p388 cells for synthesis of DNA (in vitro), ED50 = 0.996 μM. 6169834
B104-1-1 Growth inhibitory assay Growth inhibitory activity was tested against B104-1-1 cells, GI50 = 0.0007 μM. 10888331
Hep G2 Cytotoxicity assay Cytotoxicity against human Hep G2 cells, GI50 = 0.0012 μM. 16933866
HM02 Cytotoxicity assay Cytotoxicity against human HM02 cells, GI50 = 0.0016 μM. 16933866
L1210 Function assay Inhibition of synthesis of [5-3H]-uridine into RNA in L1210 cells., IC50 = 0.019 μM. 3397991
L1210 Function assay Inhibition of synthesis of [methyl-14C] thymidine into DNA, in L1210 cells., IC50 = 0.38 μM. 3397991
Jurkat T Function assay Inhibitory concentration against Human Jurkat T cells, IC50 = 0.0045 μM. 10212121
B104-1-1 Function assay In vitro binding assay of Shc-derived phosphopeptide to Growth factor receptor bound protein 2 SH2 in B104-1-1 cells was determined, IC50 = 5 μM. 10888331
C8166 Antitumor assay Antitumor activity against CD+ human acute T-lymphoblastic leukemia C8166 cells, IC50 = 0.0008 μM. 12431048
CCRF-CEM Antitumor assay Antitumor activity against human acute T-lymphoblastic leukemia CCRF-CEM cells, IC50 = 0.001 μM. 12431048
CD4+T Antitumor assay Antitumor activity against human CD4+T cells expressing the TAT gene of HTLV-1 MT-4 cells, IC50 = 0.001 μM. 12431048
MOLT-4 Antitumor assay Antitumor activity against human acute T-lymphoblastic leukemia MOLT-4 cells, IC50 = 0.001 μM. 12431048
G-361 Antitumor assay Antitumor activity against human skin melanoma G-361 cells, IC50 = 0.001 μM. 12431048
MT-4 Antitumor assay Antitumor activity against CD+ human acute T-lymphoblastic leukemia MT-4 cells, IC50 = 0.001 μM. 12431048
CCRF-SB Antitumor assay Antitumor activity against human acute B-lymphoblastic leukemia CCRF-SB cells, IC50 = 0.002 μM. 12431048
SKMEK-28 Antitumor assay Antitumor activity against human skin melanoma SKMEK-28 cells, IC50 = 0.002 μM. 12431048
Raji Antitumor assay Antitumor activity against human Burkitt lym phoma Raji cells, IC50 = 0.002 μM. 12431048
5637 Antitumor assay Antitumor activity against human bladder carcinoma 5637 cells, IC50 = 0.003 μM. 12431048
Wil2-NS Antitumor assay Anti tumor activity against human splenic B-lympho blastoid Wil2-NS cells, IC50 = 0.003 μM. 12431048
Hep-2 Antitumor assay Antitumor activity against larynx carcinoma Hep-2 cells, IC50 = 0.004 μM. 12431048
SK-MES-1 Antitumor assay Antitumor activity against human lung squamous carcinoma SK-MES-1 cells, IC50 = 0.004 μM. 12431048
ACHN Antitumor assay Antitumor activity against human renal adenocarcinoma ACHN cells, IC50 = 0.005 μM. 12431048
KB Function assay Compound concentration required to reduce the cell proliferation of Wild type and Drug- resistant human nasopharyngeal carcinoma KB cells by 50%, IC50 = 0.005 μM. 12431048
HT-29 Antitumor assay Antitumor activity against human colon adenocarcinoma HT-29 cells, IC50 = 0.006 μM. 12431048
MCF-7 Antitumor assay Antitumor activity against human breast adenocarcinoma MCF-7 cells, IC50 = 0.006 μM. 12431048
CRL7065 Antitumor assay Antitumor activity against human foreskin fibroblasts CRL7065 cells, IC50 = 0.007 μM. 12431048
DU145 Antitumor assay Antitumor activity against human prostate carcinoma DU145 cells, IC50 = 0.008 μM. 12431048
Hela Antitumor assay Antitumor activity against cervix carcinoma Hela cells cells, IC50 = 0.008 μM. 12431048
HepG2 Antitumor assay Antitumor activity against human hepatocellular carcinoma HepG2 cells, IC50 = 0.01 μM. 12431048
C8166 Antitumor assay Antitumor activity against CD4+ human acute T-lymphoblastic C8166 leukemia cells., IC50 = 0.00008 μM. 12431049
MT-4 Antitumor assay Antitumor activity against CD4+ human acute T-lymphoblastic MT-4 leukemia cells., IC50 = 0.0009 μM. 12431049
G361 Antitumor assay Antitumor activity against human skin melanoma G361 cells., IC50 = 0.001 μM. 12431049
MOLT-4 Antitumor assay Antitumor activity against human acute T-lymphoblastic MOLT-4 leukemia cells., IC50 = 0.001 μM. 12431049
CCRF-SB Antitumor assay Antitumor activity against human acute B-lymphoblastic CCRF-SB leukemia cells., IC50 = 0.001 μM. 12431049
Raji Antitumor assay Antitumor activity against human Burkitt lymphoma Raji cells., IC50 = 0.002 μM. 12431049
5637 Antitumor assay Antitumor activity against human bladder carcinoma 5637 cells., IC50 = 0.003 μM. 12431049
CCRF-CEM Antitumor assay Antitumor activity against human acute T-lymphoblastic CCRF-CEM leukemia cells., IC50 = 0.003 μM. 12431049
Wil-NS Antitumor assay Antitumor activity against human splenic B-lymphoblastoid Wil-NS cells., IC50 = 0.003 μM. 12431049
Hep-2 Antitumor assay Antitumor activity against Hep-2 larynx carcinoma cells., IC50 = 0.004 μM. 12431049
ACHN Antitumor assay Antitumor activity against human renal adenocarcinoma ACHN cells., IC50 = 0.005 μM. 12431049
MCF-7 Antitumor assay Antitumor activity against human breast adenocarcinoma MCF-7 cells., IC50 = 0.006 μM. 12431049
HT-29 Antitumor assay Antitumor activity against human colon adenocarcinoma HT-29 cells., IC50 = 0.006 μM. 12431049
HepG-2 Antitumor assay Antitumor activity against human hepatocellular carcinoma HepG-2 cells., IC50 = 0.01 μM. 12431049
HeLa Antitumor assay Antitumor activity against HeLa cervical carcinoma cells., IC50 = 0.04 μM. 12431049
CCRF-CEM Cytotoxicity assay Cytotoxicity in human leukemic CCRF-CEM cells., IC50 = 1.6 μM. 14667232
A2780 Cytotoxicity assay Cytotoxicity against human A2780 cells, IC50 = 0.0008 μM. 15844934
A2780 Cytotoxicity assay Cytotoxicity against human A2780 cells, IC50 = 0.0008 μM. 16180816
MOLT3 Cytotoxicity assay Cytotoxicity against MOLT3 Leukemia cells by MTS assay, IC50 = 1 μM. 16420056
U937 Cytotoxicity assay Cytotoxicity against U937 Lymphoma cells by MTS assay, IC50 = 1 μM. 16420056
Vero Cytotoxicity assay Cytotoxicity against normal vero kidney cells by MTS assay, IC50 = 11 μM. 16420056
Wil2-NS Antiproliferative assay Antiproliferative activity against human Wil2-NS cells by MTT assay, IC50 = 0.003 μM. 16913700
HeLa Antiproliferative assay Antiproliferative activity against human HeLa cells by MTT assay, IC50 = 0.04 μM. 16913700
B16 Growth inhibition assay In vitro 50% Growth inhibition of sensitive B16 cells., ID50 = 0.003 μM. 3397991
L1210 Growth inhibition assay 50% Inhibition of growth of L1210 cells in culture., ID50 = 0.0601 μM. 3397991
P388/ADR Growth inhibition assay In vitro 50% Growth inhibition of actinomycin resistant P388/ADR cells, ID50 = 2.5 μM. 3397991
HeLa Apoptosis assay Induction of apoptosis in human HeLa cells assessed as DNA fragmentation by agarose gel electrophoresis 22705001
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells 29435139
U-2 OS qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
DAOY qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells 29435139
RD qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells 29435139
DAOY qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells 29435139
U-2 OS qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SK-N-SH cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells 29435139
Daoy qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for Daoy cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for TC32 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for MG 63 (6-TG R) cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SJ-GBM2 cells 29435139
RD qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for RD cells 29435139
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生物活性

產(chǎn)品描述 Actinomycin D (Dactinomycin, Act D, RASP-101)是一種從鏈霉菌屬的土壤細(xì)菌中分離出來(lái)的重要的多肽抗生素。Actinomycin D (Dactinomycin) 可抑制 DNA repair，并使 cell cycle 停滯在G1期，其IC50值分別為0.42 μM和0.4 nM。Actinomycin D (Dactinomycin) 是 autophagy 的激活劑，可在高危慢性淋巴細(xì)胞性白血病中誘導(dǎo)p53依賴性細(xì)胞的死亡并延長(zhǎng)生存期。此產(chǎn)品為?；罚毙远拘?易燃/皮膚腐蝕），請(qǐng)?jiān)诖┐鞣雷o(hù)面罩、防護(hù)手套和防護(hù)服后使用。
靶點(diǎn)
autophagy [3] cell cycle [1]
(Cell-based assay)		 DNA repair [2]
(Cell-free assay)
0.4 nM 0.42 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06252285 Recruiting
RSV Immunisation
Sanofi Pasteur a Sanofi Company|Sanofi
 February 6 2024 Phase 3
NCT05858723 Not yet recruiting
Allergic Contact Dermatitis
National Allergy Research Center Denmark
 August 2023 Not Applicable

化學(xué)信息&溶解度

分子量 1255.42 分子式

C62H86N12O16
CAS號(hào) 50-76-0 SDF --
儲(chǔ)存條件(自收到貨起) 3年 -20°C(避光) 粉狀

體外溶解度
批次：

DMSO : 100 mg/mL ( (79.65 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器
澄清溶液 3.75mg/ml (2.99mM) 以 1 mL 工作液為例，取50μL75mg/ml的澄清DMSO儲(chǔ)備液加到400μL PEG300中，混合均勻使其澄清；向上述體系中加入50μLTween80，混合均勻使其澄清；然后繼續(xù)加入500μL ddH2O定容至 1 mL。工作液請(qǐng)現(xiàn)配現(xiàn)用！

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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