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Vincristine sulfate

別名: Leurocristine sulfate, NSC-67574 sulfate, 22-Oxovincaleukoblastine sulfate 中文名稱：硫酸長春新堿

Vincristine sulfate通過與微管蛋白結(jié)合而抑制微管聚合，IC50為32 μM。Vincristine sulfate可誘導凋亡。

Vincristine sulfate Chemical Structure

Vincristine sulfate Chemical Structure

CAS: 2068-78-2

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 734.41 現(xiàn)貨
10mg 582.05 現(xiàn)貨
50mg 2229.59 現(xiàn)貨
200mg 7118.45 現(xiàn)貨
1g 24324.3 現(xiàn)貨
更大包裝 有超大折扣

400-668-6834

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Vincristine sulfate相關產(chǎn)品

細胞實驗數(shù)據(jù)示例

細胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻信息
H1299/ICAM-3 Cell Viability Assay 0-20 nM 96 h inhibits cell viability dose dependently 24177012
NCI-H1299/pcDNA3 Cell Viability Assay 0-20 nM 96 h inhibits cell viability dose dependently 24177012
Ramos Apoptosis Assay 2?μM 48 h induces 34.6%±1.92% apoptosis 24256491
CCD18Co Growth Inhibition Assay 0-1000 nM 48 h inhibits cell growth dose dependently 24403453
DLD-1 Growth Inhibition Assay 0-1000 nM 48 h inhibits cell growth dose dependently 24403453
CCD18Co Function Assay 100 nM 48 h promotes RUNX3 demethylation? 24403453
DLD-1 Function Assay 100 nM 48 h promotes RUNX3 demethylation? 24403453
U-251MG Growth Inhibition Assay 0.1?μM 24/72 h inhibits cell growth time dependently 24530235
A-172? Growth Inhibition Assay 0.1?μM 24/72 h inhibits cell growth time dependently 24530235
SUDHL6? Function Assay 1?μM 72 h induces significant apoptotic morphology changes cotrested with BCL11A siRNA 24961604
SUDHL6? Growth Inhibition Assay 1?μM 48/72 h inhibits cell viability significantly 24961604
P12 Growth Inhibition Assay 1-3 nM 48?h decreases viable cell numbers dose dependently 25156146
CEM Growth Inhibition Assay 1-3 nM 48?h decreases viable cell numbers dose dependently 25156146
Jurkat Growth Inhibition Assay 1-3 nM 48?h decreases viable cell numbers dose dependently 25156146
SK-MEL-28? Function Assay 30 nM 6 h induces G2–M cell-cycle arrest 25313010
Raji Function Assay 0.5?μM 72 h abolishes autophagy? 25446377
HepG2-HBV1.1 Growth Inhibition Assay 0.1 μM 12-72 h induces cell cycle arrest at S-phase 25663769
HepG2-HBV1.1 Growth Inhibition Assay 0.1 μM 12-72 h induces cell cycle arrest at S-phase 25663769
HepG2-HBV1.1 Growth Inhibition Assay 0.1 μM 1-5 d inhibits the proliferation time dependently 25663769
HepG2-HBV1.1 Growth Inhibition Assay 0.1 μM 1-5 d inhibits the proliferation time dependently 25663769
HepG2-HBV1.1 Function Assay 0.1 μM 48 h promotes cell excretion of hepatitis B virus nucleocapsids instead of hepatitis B virus Dane particles 25663769
HepG2-HBV1.1 Function Assay 0.1 μM 24 h promotes hepatitis B virus protein expression 25663769
HepG2.2.15 Function Assay 0.1 μM 24 h promotes hepatitis B virus protein expression 25663769
HepG2-HBV1.1 Apoptosis Assay 0-0.5 μM 24 h induces apoptosis dose dependently 25663769
HepG2.2.15 Cell Viability Assay 0-0.5 μM 24 h decreases cell viability dose dependently 25663769
NCI-H1299/pcDNA3 Function Assay 1/5/10/20?nM 96 h induces cleavage of caspases-3, 8, 9, and PARP 24177012
H1299/ICAM-3 Function Assay 1/5/10/20?nM 96 h induces cleavage of caspases-3, 8, 9, and PARP 24177012
K562 Apoptosis Assay 0.3 μM 24 h induces apoptosis significantly 24135937
K562/ADR Apoptosis Assay 3 μM 24 h induces apoptosis 24135937
K562 Cell Viability Assay 3.75–60?nM 72?h? inhibits cell viability dose dependently 23877223
lucena Cell Viability Assay 3.75–60?nM 72?h? no effect 23877223
FEPS Cell Viability Assay 3.75–60?nM 72?h? no effect 23877223
Jurkat Apoptosis Assay 5?μg/ml? 24 h induces apoptosis significantly 23810409
Jurkat Growth Inhibition Assay 5?μg/ml? 24 h arrest Jurkat cells in G2/M phase 23810409
SGC-7901 Growth Inhibition Assay 0-10 μg/ml 24/48/72 h inhibits cell growth in dose and time dependent manner 23743572
SGC-7901/VCR Growth Inhibition Assay 0-10 μg/ml 24/48/72 h inhibits cell growth in dose and time dependent manner 23743572
JFCR39? Growth Inhibition Assay 1 μM 24 h markedly increases the number of G2/M phase cells 23598276
A549 Function Assay 100 nM 16 h leads to a loss of microtubules 23598276
SH-SY5Y? Growth Inhibition Assay 0.001-10 μM 24 h IC50=0.113±0.012 μM 23129065
SH-SY5Y? Growth Inhibition Assay 0.001-10 μM 48 h IC50=0.078±0.009 μM 23129065
SH-SY5Y? Growth Inhibition Assay 0.001-10 μM 72 h IC50=0.051±0.008 μM 23129065
SH-SY5Y Apoptosis Assay 0.1 μM 0-24 h induces apoptosis of SH-SY5Y cells following cell cycle arrest at the G2/M phase 23129065
SH-SY5Y Apoptosis Assay 0.1 μM 0-24 h induces mitotic arrest? 23129065
A549/EGFP? Growth Inhibition Assay 0.01-1000 μM IC50=86.7 ± 29.1 μM 23634282
A549/Slug Growth Inhibition Assay 0.01-1000 μM IC50=9.7 ± 3.1 μM 23634282
HepG2 Growth Inhibition Assay 24 h IC50=52.5?μM 24341688
TCC Growth Inhibition Assay 48 h IC50=50 nM 24716944
TCC Growth Inhibition Assay 24 h IC50=70 nM 24716944
LNCAP Cytotoxicity assay 72 hrs Cytotoxicity against human LNCAP cells after 72 hrs by alamar blue assay, IC50 = 0.0029 μM. 20732809
LNCAP Cytotoxicity assay 72 hrs Cytotoxicity against human LNCAP cells after 72 hrs by alamar blue assay, IC50 = 0.0061 μM. 23215348
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay, IC50 = 0.011 μM. 20732809
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay, IC50 = 0.015 μM. 23215348
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 72 hrs by alamar blue assay, IC50 = 0.0153 μM. 23489291
NFF Cytotoxicity assay 72 hrs Cytotoxicity against human NFF cells assessed as inhibition of cell viability after 72 hrs by alamar blue assay, IC50 = 0.0169 μM. 23489291
NFF Cytotoxicity assay 72 hrs Cytotoxicity against human NFF cells after 72 hrs by alamar blue assay, IC50 = 0.017 μM. 23215348
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay, IC50 = 0.02 μM. 23215348
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50 = 0.02 μM. 26522953
PC3 Antiproliferative assay 48 hrs Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, IC50 = 0.0276 μM. 28038323
HEK Cytotoxicity assay 72 hrs Cytotoxicity against human HEK cells after 72 hrs by alamar blue assay, IC50 = 0.031 μM. 23215348
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 72 hrs by alamar blue assay, IC50 = 0.0358 μM. 23489291
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay, IC50 = 0.036 μM. 23215348
BT549 Antiproliferative assay 48 hrs Antiproliferative activity against human BT549 cells after 48 hrs by MTT assay, IC50 = 0.05472 μM. 28038323
DU145 Antiproliferative assay 48 hrs Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 0.0723 μM. 28038323
Leukemia cells Antitumor assay 48 hrs Antitumor activity against human Leukemia cells after 48 hrs by SRB assay, GI50 = 0.1 μM. 19006285
Leukemia cells Antitumor assay 48 hrs Antitumor activity against human Leukemia cells after 48 hrs by SRB assay, GI = 0.1 μM. 19006285
Colon cancer cells Antitumor assay 48 hrs Antitumor activity against human Colon cancer cells after 48 hrs by SRB assay, GI50 = 0.1 μM. 19006285
Colon cancer cells Antitumor assay 48 hrs Antitumor activity against human Colon cancer cells after 48 hrs by SRB assay, GI = 0.1 μM. 19006285
Leukemia cells Growth inhibition assay 48 hrs Growth inhibition of human leukemia cells after 48 hrs, GI50 = 0.1 μM. 20684599
Colon cancer cells Growth inhibition assay 48 hrs Growth inhibition of human colon cancer cells after 48 hrs, GI50 = 0.1 μM. 20684599
Leukemia cells Cytotoxicity assay 48 hrs Cytotoxicity against human leukemia cells after 48 hrs, GI50 = 0.1 μM. 24747749
Colon cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human colon cancer cells after 48 hrs, GI50 = 0.1 μM. 24747749
Leukemia cells Cytotoxicity assay 48 hrs Cytotoxicity against human leukemia cells after 48 hrs, GI50 = 0.1 μM. 22283430
Colon cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human COLON cells after 48 hrs, GI50 = 0.1 μM. 22283430
MDA-MB-231 Antiproliferative assay 48 hrs Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 0.1166 μM. 28038323
CNS Antitumor assay 48 hrs Antitumor activity against human CNS cancer cells after 48 hrs by SRB assay, GI50 = 0.12589 μM. 19006285
prostate cancer cells Antitumor assay 48 hrs Antitumor activity against human prostate cancer cells after 48 hrs by SRB assay, GI50 = 0.12589 μM. 19006285
CNS Antitumor assay 48 hrs Antitumor activity against human CNS cancer cells after 48 hrs by SRB assay, GI = 0.13 μM. 19006285
prostate cancer cells Antitumor assay 48 hrs Antitumor activity against human prostate cancer cells after 48 hrs by SRB assay, GI = 0.13 μM. 19006285
prostate cancer cells Growth inhibition assay 48 hrs Growth inhibition of human prostate cancer cells after 48 hrs, GI50 = 0.13 μM. 20684599
CNS Growth inhibition assay 48 hrs Growth inhibition of human CNS cancer cells after 48 hrs, GI50 = 0.13 μM. 20684599
CNS Cytotoxicity assay 48 hrs Cytotoxicity against human CNS cancer cells after 48 hrs, GI50 = 0.13 μM. 24747749
prostate cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human prostate cancer cells after 48 hrs, GI50 = 0.13 μM. 24747749
prostate cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human prostate cancer cells after 48 hrs, GI50 = 0.13 μM. 22283430
CNS Cytotoxicity assay 48 hrs Cytotoxicity against human CNS cancer cells after 48 hrs, GI50 = 0.13 μM. 22283430
Melanoma cells Antitumor assay 48 hrs Antitumor activity against human Melanoma cells after 48 hrs by SRB assay, GI50 = 0.15849 μM. 19006285
Melanoma cells Antitumor assay 48 hrs Antitumor activity against human Melanoma cells after 48 hrs by SRB assay, GI = 0.16 μM. 19006285
Melanoma cells Cytotoxicity assay 48 hrs Cytotoxicity against human melanoma cells after 48 hrs, GI50 = 0.16 μM. 24747749
Melanoma cells Cytotoxicity assay 48 hrs Cytotoxicity against human melanoma cells after 48 hrs, GI50 = 0.16 μM. 22283430
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 0.1715 μM. 28038323
NSCLC Antitumor assay 48 hrs Antitumor activity against human NSCLC cells after 48 hrs by SRB assay, GI = 0.25 μM. 19006285
NSCLC Growth inhibition assay 48 hrs Growth inhibition of human NSCLC cells after 48 hrs, GI50 = 0.25 μM. 20684599
NSCLC Cytotoxicity assay 48 hrs Cytotoxicity against human NSCLC cells after 48 hrs, GI50 = 0.25 μM. 22283430
NSCLC Cytotoxicity assay 48 hrs Cytotoxicity against human NSCLC cells after 48 hrs, GI50 = 0.25 μM. 24747749
NSCLC Antitumor assay 48 hrs Antitumor activity against human NSCLC cells after 48 hrs by SRB assay, GI50 = 0.25119 μM. 19006285
ovarian cancer cells Antitumor assay 48 hrs Antitumor activity against human ovarian cancer cells after 48 hrs by SRB assay, GI50 = 0.31623 μM. 19006285
renal cancer cells Antitumor assay 48 hrs Antitumor activity against human renal cancer cells after 48 hrs by SRB assay, GI50 = 0.31623 μM. 19006285
breast cancer cells Antitumor assay 48 hrs Antitumor activity against human Breast cancer cells after 48 hrs by SRB assay, GI50 = 0.31623 μM. 19006285
ovarian cancer cells Antitumor assay 48 hrs Antitumor activity against human ovarian cancer cells after 48 hrs by SRB assay, GI = 0.32 μM. 19006285
renal cancer cells Antitumor assay 48 hrs Antitumor activity against human renal cancer cells after 48 hrs by SRB assay, GI = 0.32 μM. 19006285
breast cancer cells Antitumor assay 48 hrs Antitumor activity against human Breast cancer cells after 48 hrs by SRB assay, GI = 0.32 μM. 19006285
renal cancer cells Growth inhibition assay 48 hrs Growth inhibition of human renal cancer cells after 48 hrs, GI50 = 0.32 μM. 20684599
breast cancer cells Growth inhibition assay 48 hrs Growth inhibition of human breast cancer cells after 48 hrs, GI50 = 0.32 μM. 20684599
ovarian cancer cells Growth inhibition assay 48 hrs Growth inhibition of human Ovarian cancer cells after 48 hrs, GI50 = 0.32 μM. 20684599
breast cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human breast cancer cells after 48 hrs, GI50 = 0.32 μM. 24747749
renal cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human renal cancer cells after 48 hrs, GI50 = 0.32 μM. 24747749
ovarian cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human ovarian cancer cells after 48 hrs, GI50 = 0.32 μM. 24747749
renal cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human renal cancer cells after 48 hrs, GI50 = 0.32 μM. 22283430
ovarian cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human ovarian cancer cells after 48 hrs, GI50 = 0.32 μM. 22283430
breast cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human breast cancer cells after 48 hrs, GI50 = 0.32 μM. 22283430
Lu1 Cytotoxicity assay 72 hrs Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay, IC50 = 0.48 μM. 26522953
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50 = 0.51 μM. 26522953
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay, IC50 = 0.69 μM. 26522953
COLON Growth inhibition assay 48 hrs Growth inhibition of human colon cancer cells after 48 hrs, TGI = 3.98 μM. 20684599
COLON Cytotoxicity assay 48 hrs Cytotoxicity against human colon cancer cells after 48 hrs, TGI = 3.98 μM. 24747749
COLON Cytotoxicity assay 48 hrs Cytotoxicity against human COLON cells after 48 hrs, TGI = 3.98 μM. 22283430
COLON Antitumor assay 48 hrs Antitumor activity against human Colon cancer cells after 48 hrs by SRB assay, TGI = 3.98107 μM. 19006285
CNS Antitumor assay 48 hrs Antitumor activity against human CNS cancer cells after 48 hrs by SRB assay, TGI = 6.30957 μM. 19006285
prostate cancer cells Antitumor assay 48 hrs Antitumor activity against human prostate cancer cells after 48 hrs by SRB assay, TGI = 6.30957 μM. 19006285
prostate cancer cells Growth inhibition assay 48 hrs Growth inhibition of human prostate cancer cells after 48 hrs, TGI = 6.31 μM. 20684599
CNS Growth inhibition assay 48 hrs Growth inhibition of human CNS cancer cells after 48 hrs, TGI = 6.31 μM. 20684599
CNS Cytotoxicity assay 48 hrs Cytotoxicity against human CNS cancer cells after 48 hrs, TGI = 6.31 μM. 24747749
prostate cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human prostate cancer cells after 48 hrs, TGI = 6.31 μM. 24747749
prostate cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human prostate cancer cells after 48 hrs, TGI = 6.31 μM. 22283430
CNS Cytotoxicity assay 48 hrs Cytotoxicity against human CNS cancer cells after 48 hrs, TGI = 6.31 μM. 22283430
Melanoma cells Growth inhibition assay 48 hrs Growth inhibition of human melanoma cells after 48 hrs, TGI = 7.94 μM. 20684599
breast cancer cells Growth inhibition assay 48 hrs Growth inhibition of human breast cancer cells after 48 hrs, TGI = 7.94 μM. 20684599
breast cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human breast cancer cells after 48 hrs, TGI = 7.94 μM. 24747749
Melanoma cells Cytotoxicity assay 48 hrs Cytotoxicity against human melanoma cells after 48 hrs, TGI = 7.94 μM. 24747749
Melanoma cells Cytotoxicity assay 48 hrs Cytotoxicity against human melanoma cells after 48 hrs, TGI = 7.94 μM. 22283430
breast cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human breast cancer cells after 48 hrs, TGI = 7.94 μM. 22283430
Melanoma cells Antitumor assay 48 hrs Antitumor activity against human Melanoma cells after 48 hrs by SRB assay, TGI = 7.94328 μM. 19006285
breast cancer cells Antitumor assay 48 hrs Antitumor activity against human Breast cancer cells after 48 hrs by SRB assay, TGI = 7.94328 μM. 19006285
Leukemia cells Antitumor assay 48 hrs Antitumor activity against human Leukemia cells after 48 hrs by SRB assay, TGI = 15.8489 μM. 19006285
NSCLC Antitumor assay 48 hrs Antitumor activity against human NSCLC cells after 48 hrs by SRB assay, TGI = 15.8489 μM. 19006285
NSCLC Growth inhibition assay 48 hrs Growth inhibition of human NSCLC cells after 48 hrs, TGI = 15.85 μM. 20684599
Leukemia cells Growth inhibition assay 48 hrs Growth inhibition of human leukemia cells after 48 hrs, TGI = 15.85 μM. 20684599
NSCLC Cytotoxicity assay 48 hrs Cytotoxicity against human NSCLC cells after 48 hrs, TGI = 15.85 μM. 22283430
Leukemia cells Cytotoxicity assay 48 hrs Cytotoxicity against human leukemia cells after 48 hrs, TGI = 15.85 μM. 24747749
NSCLC Cytotoxicity assay 48 hrs Cytotoxicity against human NSCLC cells after 48 hrs, TGI = 15.85 μM. 24747749
Leukemia cells Cytotoxicity assay 48 hrs Cytotoxicity against human leukemia cells after 48 hrs, TGI = 15.85 μM. 22283430
renal cancer cells Growth inhibition assay 48 hrs Growth inhibition of human renal cancer cells after 48 hrs, TGI = 19.95 μM. 20684599
ovarian cancer cells Growth inhibition assay 48 hrs Growth inhibition of human Ovarian cancer cells after 48 hrs, TGI = 19.95 μM. 20684599
renal cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human renal cancer cells after 48 hrs, TGI = 19.95 μM. 24747749
ovarian cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human ovarian cancer cells after 48 hrs, TGI = 19.95 μM. 24747749
renal cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human renal cancer cells after 48 hrs, TGI = 19.95 μM. 22283430
ovarian cancer cells Cytotoxicity assay 48 hrs Cytotoxicity against human ovarian cancer cells after 48 hrs, TGI = 19.95 μM. 22283430
ovarian cancer cells Antitumor assay 48 hrs Antitumor activity against human ovarian cancer cells after 48 hrs by SRB assay, TGI = 19.9526 μM. 19006285
renal cancer cells Antitumor assay 48 hrs Antitumor activity against human renal cancer cells after 48 hrs by SRB assay, TGI = 19.9526 μM. 19006285
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay, IC50 = 28.11 μM. 29174816
HEK293/MRP1 Growth Inhibition Assay IC50=0.055±0.0120 μM 24284783
HEK293/pcDNA3.1 Growth Inhibition Assay IC50=0.004±0.0003 μM 24284783
MCF-7 Growth Inhibition Assay IC50=0.0159±0.0062 μM 24704556
MCF-7/ADR Growth Inhibition Assay IC50=4.4826±0.2070 μM 24704556
HepG2 Growth Inhibition Assay IC50=0.0115±0.0017 μM 24704556
HepG2/ADM Growth Inhibition Assay IC50=2.7863±0.2371 μM 24704556
HEK293/ABCC1 Growth Inhibition Assay IC50=19.29 ± 2.08 nM 24726739
HEK293/pcDNA3.1 Growth Inhibition Assay IC50=1.45 ± 0.20 nM 24726739
SW620/AD300 Growth Inhibition Assay IC50=909.60 ± 8.91 nM 24726739
SW620 Growth Inhibition Assay IC50=7.80 ± 0.08 nM 24726739
MCF-7-R Cytotoxicity Assay IC50=5.539 ± 0.144 nM 24858827
A549-R Cytotoxicity Assay IC50=12.178 ± 0.333 nM 24858827
MCF-7-R Growth Inhibition Assay IC50=5.539 ± 0.144 nM 24858827
MCF-7-WT Growth Inhibition Assay IC50=17.752 ± 0.218 nM 24858827
A549-R Growth Inhibition Assay IC50=12.178 ± 0.333 nM 24858827
A549-WT Growth Inhibition Assay IC50=19.437 ± 0.594 nM 24858827
SHSY5Y Growth Inhibition Assay IC50=8.2±0.6 nM 24921920
LAN1 Growth Inhibition Assay IC50=2.3±0.2 nM 24921920
SKNAS Growth Inhibition Assay IC50=1.5±0.2 nM 24921920
IGNR91 Growth Inhibition Assay IC50=24.3±1.7 nM 24921920
SKNBe2C Growth Inhibition Assay IC50=32.8±4.0 nM 24921920
HCT-116 Growth Inhibition Assay GI50=5 nM 24927857
KBv200 (ABCB1) Growth Inhibition Assay IC50=0.3462 ± 0.0066 μM 25058526
KB Growth Inhibition Assay IC50=0.0049 ± 0.0001 μM 25058526
H157 Growth Inhibition Assay IC50=1.03 ± 0.04 miu2M 25257911
W1 Growth Inhibition Assay IC50=0.0032 μM 24140176
W1VR Growth Inhibition Assay IC50=0.056 μM 24140176
K562 Growth Inhibition Assay IC50=0.032 ± 0.001 μM 24135937
K562/ADR Growth Inhibition Assay IC50=3.261 ± 0.412 μM 24135937
A549 Growth Inhibition Assay IC50=0.10 ± 0.03 μM 23971075
A2780 Growth Inhibition Assay IC50=3.5 mM 23829203
ACHN Growth Inhibition Assay IC50<0.1 mM 23829203
U-937 Growth Inhibition Assay IC50<34 nM 23829203
Hep-2 Growth Inhibition Assay IC50=0.04±0.01 μM 23780424
Hep-2/v Growth Inhibition Assay IC50=1.8±0.20 μM 23780424
SGC-7901 Apoptosis Assay induces apoptosis significantly 23743572
SGC-7901/VCR Apoptosis Assay induces apoptosis significantly 23743572
KB-3-1 Growth Inhibition Assay IC50=1.66 ± 0.162 μM 23673445
KB-C2 Growth Inhibition Assay IC50=202.56 ± 42.481 μM 23673445
KB-3-1 Growth Inhibition Assay IC50=1.26 ± 0.027 μM 23673445
KB-V1 Growth Inhibition Assay IC50=208.85 ± 20.4 μM 23673445
HEK293/pcDNA3.1 Growth Inhibition Assay IC50=24.1 ± 0.204 μM 23673445
HEK293/ABCB1 Growth Inhibition Assay IC50=3512.8 ± 378.391 μM 23673445
SGC7901 Growth Inhibition Assay IC50=1.26?±?0.11 μg/ml 23564482
SGC7901/LV-NC Growth Inhibition Assay IC50=1.77?±?0.16 μg/ml 23564482
SGC7901/LV-SGO1 Growth Inhibition Assay IC50=4.36?±?0.37 μg/ml 23564482
SGC7901/VCR Growth Inhibition Assay IC53=20.53?±?1.96 μg/ml 23564482
SGC7901/VCR-NC Growth Inhibition Assay IC50=19.86?±?2.01 μg/ml 23564482
SGC7901/VCR-si-SGO1 Growth Inhibition Assay IC50=6.18?±?1.03 μg/ml 23564482
SGC7901/ADR Growth Inhibition Assay IC50=7.85?±?0.64 μg/ml 23564482
SGC7901/ADR-NC Growth Inhibition Assay IC50=8.93?±?0.68 μg/ml 23564482
SGC7901/ADR-si-SGO1 Growth Inhibition Assay IC50=3.46?±?0.29 μg/ml 23564482
Colon cancer cells Cytotoxicity assay Cytotoxicity against human colon cancer cells, GI50 = 0.1 μM. 18598018
Leukemia cells Cytotoxicity assay Cytotoxicity against human leukemia cells, GI50 = 0.1 μM. 18598018
Leukemia cells Antitumor assay Antitumor activity against leukemia cells, GI50 = 0.1 μM. 17559205
Colon cancer cells Antitumor assay Antitumor activity against colon tumor cells, GI50 = 0.1 μM. 17559205
central nervous system cancer cells Cytotoxicity assay Cytotoxicity against human central nervous system cancer cells, GI50 = 0.12589 μM. 18598018
prostate cancer cells Cytotoxicity assay Cytotoxicity against human prostate cancer cells, GI50 = 0.12589 μM. 18598018
CNS Antitumor assay Antitumor activity against CNS tumor cells, GI50 = 0.12589 μM. 17559205
prostate cancer cells Antitumor assay Antitumor activity against prostate tumor cells, GI50 = 0.12589 μM. 17559205
Melanoma cells Cytotoxicity assay Cytotoxicity against human melanoma cells, GI50 = 0.15849 μM. 18598018
Melanoma cells Antitumor assay Antitumor activity against melanoma cells, GI50 = 0.15849 μM. 17559205
Melanoma cells Growth inhibition assay Growth inhibition of human melanoma cells after 48 hrs, GI50 = 0.16 μM. 20684599
NSCLC Antitumor assay Antitumor activity against NSCLC cells, GI50 = 0.25119 μM. 17559205
Non-small cell lung carcinoma cells Cytotoxicity assay Cytotoxicity against human Non-small cell lung carcinoma cells, GI50 = 0.25119 μM. 18598018
ovarian cancer cells Cytotoxicity assay Cytotoxicity against human ovarian cancer cells, GI50 = 0.31623 μM. 18598018
renal cancer cells Cytotoxicity assay Cytotoxicity against human renal cancer cells, GI50 = 0.31623 μM. 18598018
breast cancer cells Cytotoxicity assay Cytotoxicity against human breast cancer cells, GI50 = 0.31623 μM. 18598018
renal cancer cells Antitumor assay Antitumor activity against renal tumor cells, GI50 = 0.31623 μM. 17559205
ovarian cancer cells Antitumor assay Antitumor activity against ovarian tumor cells, GI50 = 0.31623 μM. 17559205
breast cancer cells Antitumor assay Antitumor activity against breast tumor cells, GI50 = 0.31623 μM. 17559205
COLON Cytotoxicity assay Cytotoxicity against human colon cancer cells, TGI = 3.98107 μM. 18598018
COLON Antitumor assay Antitumor activity against colon tumor cells, TGI = 3.98107 μM. 17559205
central nervous system cancer cells Cytotoxicity assay Cytotoxicity against human central nervous system cancer cells, TGI = 6.30957 μM. 18598018
prostate cancer cells Cytotoxicity assay Cytotoxicity against human prostate cancer cells, TGI = 6.30957 μM. 18598018
CNS Antitumor assay Antitumor activity against CNS tumor cells, TGI = 6.30957 μM. 17559205
prostate cancer cells Antitumor assay Antitumor activity against prostate tumor cells, TGI = 6.30957 μM. 17559205
Melanoma cells Cytotoxicity assay Cytotoxicity against human melanoma cells, TGI = 7.94328 μM. 18598018
breast cancer cells Cytotoxicity assay Cytotoxicity against human breast cancer cells, TGI = 7.94328 μM. 18598018
Melanoma cells Antitumor assay Antitumor activity against melanoma cells, TGI = 7.94328 μM. 17559205
breast tumor cells Antitumor assay Antitumor activity against breast tumor cells, TGI = 7.94328 μM. 17559205
NSCLC Antitumor assay Antitumor activity against NSCLC cells, TGI = 15.8489 μM. 17559205
Non-small cell lung carcinoma cells Cytotoxicity assay Cytotoxicity against human Non-small cell lung carcinoma cells, TGI = 15.8489 μM. 18598018
Leukemia cells Cytotoxicity assay Cytotoxicity against human leukemia cells, TGI = 15.8489 μM. 18598018
Leukemia cells Antitumor assay Antitumor activity against leukemia cells, TGI = 15.8489 μM. 17559205
ovarian cancer cells Cytotoxicity assay Cytotoxicity against human ovarian cancer cells, TGI = 19.9526 μM. 18598018
renal cancer cells Cytotoxicity assay Cytotoxicity against human renal cancer cells, TGI = 19.9526 μM. 18598018
renal tumor cells Antitumor assay Antitumor activity against renal tumor cells, TGI = 19.9526 μM. 17559205
ovarian tumor cells Antitumor assay Antitumor activity against ovarian tumor cells, TGI = 19.9526 μM. 17559205
neural precursor cells Function assay Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 17417631
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生物活性

產(chǎn)品描述 Vincristine sulfate通過與微管蛋白結(jié)合而抑制微管聚合，IC50為32 μM。Vincristine sulfate可誘導凋亡。
靶點
Microtubules [1]
(Cell-free assay)
32 μM
體外研究(In Vitro)
體外研究活性 Vincristine抑制微管蛋白二聚體聚合亞單位,抑制它們的聚合作用，Ki為85 nM。[1]在低濃度時，Vincristine抑制紡錘體，使染色體分離失敗，進而導致中期停滯，并抑制有絲分裂。在較高濃度時，Vincristine可能干擾且誘導全部微管解聚。[2] Vincristine 誘導腫瘤細胞凋亡，且抑制SH-SY5Y細胞增殖，IC50為0.1 μM。Vincristine誘導有絲分裂停滯，促進caspase-3和-9及cyclin B的表達，但降低cyclin D的表達。[3] Vincristine通過干擾微管功能而誘導神經(jīng)毒性形成，這會導致軸突運輸堵塞，從而導致軸突變性。[4]
細胞實驗 細胞系 B16 黑色素瘤細胞
濃度 10 nM
孵育時間 3 天
方法 細胞按5 × 104 cells/mL的濃度接種在含2 mL培養(yǎng)基的35-mm 實驗板上，在37°C下 含5% CO2 和95% 空氣 的環(huán)境下生長24小時。然后使用有或無10 nM藥物的新鮮培養(yǎng)基更換原來的培養(yǎng)基，繼續(xù)增殖3天。使用胰蛋白酶和EDTA將細胞分離后，每天使用庫氏計數(shù)器完成細胞計數(shù)
實驗圖片 檢測方法 檢測指標 實驗圖片 PMID
Western blot MPM2 / Cyclin B1 / Cdc25c / p-Cdc2 / Cdc2 / Aurora B / p-H3 / p-PLK1 26156322
Growth inhibition assay Cell viability 26156322
體內(nèi)研究(In Vivo)
體內(nèi)研究活性 Vincristine 按3 mg/kg劑量單獨腹腔注射給藥攜帶雙側(cè)皮下移植瘤RH12或RH18的小鼠，平均生長延遲120天和52天以上，且再植指數(shù)分別為0.06％和5％。[5] Vincristine 處理小鼠，通過宿主細胞介導的血管效應及直接的微管蛋白介導的的細胞毒性作用而對皮下結(jié)腸38腫瘤起作用。Vincristine (5 mg/kg) 降低腫瘤血流量，降低近75%。[6]
動物實驗 Animal Models 攜帶人類橫紋肌肉瘤移植瘤Rh12的鼠
Dosages 3 mg/kg
Administration 腹腔注射
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05844670 Recruiting
Pediatric Cancer
Moi University|Princess Maxima Center for Pediatric Oncology|Amsterdam UMC location VUmc
 April 20 2023 Phase 4
NCT04448834 Withdrawn
B-cell Acute Lymphoblastic Leukemia
Dorothy Sipkins MD PhD|Amgen|Acrotech Biopharma Inc.|Duke University
 January 2022 Phase 2

化學信息&溶解度

分子量 923.04 分子式

C46H58N4O14S
CAS號 2068-78-2 SDF Download Vincristine sulfate SDF
Smiles CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
儲存條件(自收到貨起)

體外溶解度
批次：

DMSO : 100 mg/mL ( (108.33 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Water : 100 mg/mL (108.33 mM)

Ethanol : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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常見問題及建議解決方法

問題 1:
I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?

回答：
According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

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