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SB202190

別名: FHPI

SB202190是一種有效的p38 MAPK抑制劑，靶向作用于p38α/β，無細(xì)胞試驗(yàn)中IC50為50 nM/100 nM，有時(shí)用于代替SB 203580研究其在體內(nèi)對(duì)SAPK2a/p38的潛在作用。SB202190 可通過誘導(dǎo)自噬和血紅素氧化酶1來抑制內(nèi)皮細(xì)胞的凋亡。SB202190可顯著抑制Erastin依賴的鐵死亡ferroptosis。

SB202190 Chemical Structure

SB202190 Chemical Structure

CAS: 152121-30-7

規(guī)格 價(jià)格 庫存 購買數(shù)量
10mM (1mL in DMSO) 1091.41 現(xiàn)貨
25mg 1189.49 現(xiàn)貨
100mg 3017.14 現(xiàn)貨
1g 13677.3 現(xiàn)貨
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SB202190相關(guān)產(chǎn)品

相關(guān)信號(hào)通路圖

p38 MAPK Signaling Pathways

p38 MAPK信號(hào)通路圖

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
MKN-45 Function Assay 10?μM 30?min significantly decreases Il-1β-induced MMP2 and MMP9 mRNA expression 24479681
AGS? Function Assay 10?μM 30?min significantly decreases Il-1β-induced MMP2 and MMP9 mRNA expression 24479681
MKN-45 Function Assay 10?μM 30?min attenuates IL-1β-induced GA cell migration and invasion 24479681
AGS? Function Assay 10?μM 30?min attenuates IL-1β-induced GA cell migration and invasion 24479681
MKN-45 Function Assay 10?μM 30?min inhibits IL-1β-induced activation of p38 24479681
AGS? Function Assay 10?μM 30?min inhibits IL-1β-induced activation of p38 24479681
HUVECs? Function Assay 10?μM 1 h inhibits TNF-α-induced CXCL1 production 24487964
MC3T3-E1 Function Assay 30 μM 1 h attenuates TNF-α-stimulated p38 MAPK phosphorylation 24502696
MC3T3-E1 Function Assay 0.3/3/30 μM 1 h attenuates TNF-α-induced MMP-9 expression in a concentration-dependent manner? 24502696
H1703 Function Assay 10?μM 6 h significantly increases the levels of ubiquitin-conjugated MSH2 in pemetrexed-treated?cell line 24530475
H520 Function Assay 10?μM 6 h significantly increases the levels of ubiquitin-conjugated MSH2 in pemetrexed-treated?cell line 24530475
H1703 Function Assay 10?μM 12 h inhibits pemetrexed-elicited MSH2 protein stability 24530475
H520 Function Assay 10?μM 12 h inhibits pemetrexed-elicited MSH2 protein stability 24530475
H1703 Function Assay 10?μM 1 h decreases the pemetrexed-induced MSH2 mRNA and protein levels 24530475
H520 Function Assay 10?μM 1 h decreases the pemetrexed-induced MSH2 mRNA and protein levels 24530475
AGS Function Assay 5 μM 30 min suppresses?1-induced caspase-8 and caspase-3 activation 24547878
PDL? Function Assay 20?μM? 30 min significantly inhibits the tensile force-mediated BMP-2 expression 24561081
macrophages Function Assay 1?μM 4.5?h completely inhibits MT-III-induced activation of NF-κB 24808633
MDDCs Function Assay 10 μM 3.5 h blocks EBOV GP, but not VSV G mediated entry into human MDDCs 24815087
MDDCs Function Assay 0-15 μM 48 h inhibits MIP-1a, MIP-1b and RANTES production 24815087
MDDCs Function Assay 0-15 μM 48 h suppresses IFN-α and IP-10 production? 24815087
HSCs Apoptosis Assay 25 μM 24?h significantly attenuates TG-induced activated HSCs apoptosis 24961950
H9c2 Function Assay 50?μM? 12 h reduces LDH release and MMP loss 25245818
HaCaT? Function Assay 40?μM 3-24 h reduces the accumulation of ZO-1 25435485
RAW 264.7 Function Assay 10?μM 30?min attenuates the effects of OPG on osteoclast retraction 25461399
RAW 264.7 Function Assay 10?μM 30?min induces characteristic vacuolation of OCs? 25461399
WB Function Assay 20?μM? 30?min decreases the LPS- or LTA-induced IL-6 and TNF-α?production 25530682
THP-1 Function Assay 5 μM 2 h significantly attenuates secretion of IL-1α induced by 27OHChol plus FSL-1? 25598661
K562? Function Assay 0.25-1 μM 24 h suppresses resveratrol-induced H2AX phosphorylation 25619392
BxPC-3 Function Assay 10 μM 1 h enhances the autophagic effect? 25632222
PANC-1 Function Assay 10 μM 1 h enhances the autophagic effect? 25632222
K562 Function Assay 10?μM 1?h inhibits quinacrine-induced p38 MAPK phosphorylation 25684043
HPAEpiCs Function Assay 1/3/10 μM 1 h inhibits S1P time-dependently stimulated c-Jun phosphorylation 25734900
HPAEpiCs Function Assay 1/3/10 μM 1 h inhibits S1P-stimulated Akt phosphorylation ? 25734900
HPAEpiCs? Function Assay 1/3/10 μM 1 h reduces S1P-induced ICAM-1 protein and mRNA expression and promoter activity 25734900
HaCaT? Function Assay 5 μM 24 h inhibits IFN-α-induced CCL22 production levels 25834353
HaCaT? Function Assay 5 μM 24 h inhibits IFN-γ-induced CCL22 production levels 25834353
SCC25 Function Assay 20 μM 24 h increases autophagy level 25834400
MH7A? Apoptosis Assay 25 μM 24 h reverses cell cycle arrest induced by XAN and caused apoptosis of cells via activation of JNK 25862966
SK-OV-3 Growth Inhibition Assay 20?μM 2 h sensitizes cell lines to treatment with 2-DG and D-allose 25888489
OVCAR-3 Growth Inhibition Assay 20?μM 2 h sensitizes cell lines to treatment with 2-DG and D-allose 25888489
HEY Growth Inhibition Assay 20?μM 2 h sensitizes cell lines to treatment with 2-DG and D-allose 25888489
AsPC-1 Growth Inhibition Assay 20?μM 2 h sensitizes cell lines to treatment with 2-DG and D-allose 25888489
BxPC-3 Growth Inhibition Assay 20?μM 2 h sensitizes cell lines to treatment with 2-DG and D-allose 25888489
MIA PaCa-2 Growth Inhibition Assay 20?μM 2 h sensitizes cell lines to treatment with 2-DG and D-allose 25888489
MIA PaCa-2 Function Assay 20?μM 24 h enhances cleavage of PARP when combined with glucose analogs 25888489
AsPC-1 Function Assay 20?μM 24 h results in a modest inhibition of HIF-1α protein accumulation 25888489
BxPC-3 Function Assay 20?μM 24 h results in a modest inhibition of HIF-1α protein accumulation 25888489
MIA PaCa-2 Function Assay 20?μM 24 h results in a modest inhibition of HIF-1α protein accumulation 25888489
MIA PaCa-2 Function Assay 20?μM 24 h reduced lactate accumulation in combination with both 2-DG and D-allose? 25888489
HTSMCs Function Assay 0.1/1/10 μM 1 h inhibited CORM-2-induced HO-1 protein levels and mRNA expression 25921464
MG63 Apoptosis Assay 10/20/30 μM 24 h significantly decreased the apoptosis rate of MG63 induced by CdCl2 25998312
MG63 Function Assay 10/20/30 μM 24 h significantly decreases the level of phosphorylated p38 induced by CdCl2 in a concentration -dependent manner 25998312
rBMSCs Function Assay 10 μM 2.5 h depresses the phosphorylation of ERK and p38 26053266
MDA-MB-231 Function Assay 2 μM 24 h lessenes CCL2 induction by TNFα 26100848
HCT-116 Function Assay 25 μM 30 min attenuates the mRNA and protein expression of hBD-2 in responsive to DA 26223251
DCs Function Assay 20?μM 1?h decreases IL-12 production 24434636
HUVEC? Function Assay 20 μm? 5 h reduces cytokine expression levels in a concentration-dependent manner 24189062
A 549 Function Assay 50 μM 1 h decreases the level of IL-8? 24179688
H520? Function Assay 5/10 μM 1 h decreases MSH2 protein as well as mRNA levels in gefitinib-exposed cell 24138903
H1703? Function Assay 5/10 μM 1 h decreases MSH2 protein as well as mRNA levels in gefitinib-exposed cell 24138903
H520? Function Assay 10?μM 12 h decreases MSH2 mRNA and protein stability in gefitinib-treated NSCLC cells 24138903
H1703? Function Assay 10?μM 12 h decreases MSH2 mRNA and protein stability in gefitinib-treated NSCLC cells 24138903
MCF-7? Growth Inhibition Assay 10?μM 24?h inhibits the CR108-induced cell death 24128853
HPAEpiCs Function Assay 0.1/1/10 μM 1 h inhibits TNF-α-induced cPLA2?protein and mRNA expression 24069158
podocytes Function Assay 10?μM 1 h inhibits TGFβ1-induced activation of p38MAPK and Erk1/2? 24036212
MCF-7 Function Assay 10?μM 1 h reduces the WA-induced phosphorylated p38 MAPK 24019090
MCF-7 Function Assay 10?μM 24 h increases the WA-induced apoptosis 24019090
HAPI Function Assay 10/20/40?μM 1 h inhibits TCDD-induced p38/JNK MAPK phosphorylation 23969120
HAPI Function Assay 20?μM? 1 h attenuates TCDD-induced activation of iNOS and production 23969120
HepG2 Function Assay 350 nM 24 h inhibits the deguelin-induced activation of p38MAPK 23933198
AGS? Function Assay 10?μM 30 min inhibits caspase-3 activation and inhibition of ERK 23850994
HepG2 Growth Inhibition Assay 0-50 μM 48 h inhibits the proliferation in a dose dependent manner 23807508
BEL7404 Growth Inhibition Assay 0-50 μM 48 h inhibits the proliferation in a dose dependent manner 23807508
HL7702 Growth Inhibition Assay 0-50 μM 48 h inhibits the proliferation in a dose dependent manner 23807508
HepG2 Function Assay 0-50 μM 24 h inhibits the phosphorylation of p38 downstream proteins MAPKAPK2, ATF2, MSK1 and HSP27 in a dose-dependent manner 23807508
BEAS-2B Growth Inhibition Assay 10 μM 30 min reverses the decrease of cell viability induced by HCI 23784034
BEAS-2B Cytotoxity Assay 10 μM 30 min inhibited the increase in LDH and IL-8 expression 23784034
BEAS-2B Function Assay 10 μM 30 min decreases the levels of caspase-3, Bad and fas 23784034
H9c2? Function Assay 0.01/0.1/1 μM 1 h attenuates TNF-α-induced MMP-9 expression, mRNA levels, and promoter activity 23774252
H9c2? Function Assay 1 μM 1 h reduces TNF-α directly stimulated p38 MAPK phosphorylation 23774252
U937 Function Assay 10?μM? 1 h abrogates the caffeine effect on MKP-1 and PP2Acα mRNA transcriptional levels 23707387
U937 Function Assay 10?μM? 1 h abrogates caffeine-induced MKP-1 down-regulation and PP2Acα up-regulation 23707387
U937 Function Assay 10?μM? 1 h suppresses c-Jun and CREB phosphorylation in caffeine-treated cells? 23707387
A549 Function Assay 0.3/3/30 μM 1 h significantly attenuates ATPγS-mediated COX-2 protein and mRNA expression and promoter activity? 23680674
A549 Function Assay 10?μM? 0-30 min inhibits ATPγS induced p42/p44 MAPK and p38 MAPK phosphorylation 23680674
A549 Function Assay 10?μM? 1 h inhibits ATPγS induced NF-κB p65 subunit phosphorylation and NF-κB promoter activity 23680674
A549 Function Assay 10?μM? 1 h reduces ATPγS-stimulated cPLA2 phosphorylation? 23680674
A549 Function Assay 10?μM? 1 h reduces ATPγS-enhanced enzymatic activity of cPLA2? 23680674
PC12 Function Assay 10/20/40 μM 1?h inhibits JNK and p38 23584357
HK-2 Apoptosis Assay 20?μM 24 h inhibits ERK and p38MAPK 23543151
H9c2 Function Assay 1?μM 1 h reduces TNF-α-induced MMP-9 mRNA levels and promoter activity 23353699
H9c2 Function Assay 1?μM 1 h reduces TNF-α-enhanced AP-1 promoter activity 23353699
H1650? Function Assay 10?μM? 1 h decreases both protein and mRNA levels of ERCC1 in paclitaxel-exposed?cells 23228696
H1703 Function Assay 10?μM? 1 h decreases both protein and mRNA levels of ERCC1 in paclitaxel-exposed?cells 23228696
H1650? Growth Inhibition Assay 10?μM? 1 h enhances paclitaxel-induced cytotoxicity 23228696
H1703 Growth Inhibition Assay 10?μM? 1 h enhances paclitaxel-induced cytotoxicity 23228696
MDDCs Growth Inhibition Assay 72 h IC502.7μM 24815087
THP-1 Growth Inhibition Assay 72 h IC50=4.7μM 24815087
MH7A? Growth Inhibition Assay 24 h reinforces the inhibitory effects of XAN 25862966
RAW264.7 Antiinflammatory assay 10 mins Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 10 mins prior to LPS-challenge measured after 18 hrs by Griess method, IC50 = 16 μM. 22831798
BL21(DE3) Function assay 60 mins Inhibition of recombinant human N-terminal His6-tagged BRD4 expressed in Escherichia coli BL21(DE3) cells using biotinylated histone H4 peptide as substrate after 60 mins by AlphaScreen assay, IC50 = 3.4 μM. 28195723
medulloblastoma cells Antiproliferative assay Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay, EC50 = 3.006 μM. 17417631
neural precursor cells Antiproliferative assay Antiproliferative activity against mouse neural precursor cells by MTT assay, EC50 = 8.063 μM. 17417631
RAW264.7 Function assay Protection against Bacillus anthracis protective antigen and lethal toxin-diphtheria toxin chimeric protein mediated cytotoxicity in mouse RAW264.7 cells assessed as cell viability 17485504
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
DAOY qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells 29435139
RD qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells 29435139
NB1643 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells 29435139
Rh30 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
NB1643 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells 29435139
Rh18 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells 29435139
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生物活性

產(chǎn)品描述 SB202190是一種有效的p38 MAPK抑制劑，靶向作用于p38α/β，無細(xì)胞試驗(yàn)中IC50為50 nM/100 nM，有時(shí)用于代替SB 203580研究其在體內(nèi)對(duì)SAPK2a/p38的潛在作用。SB202190 可通過誘導(dǎo)自噬和血紅素氧化酶1來抑制內(nèi)皮細(xì)胞的凋亡。SB202190可顯著抑制Erastin依賴的鐵死亡ferroptosis。
特性 SB 202190 與SB 203580極為相似。
靶點(diǎn)
Ferroptosis [11] p38α [1]
(Cell-free assay)		 p38β [1]
(Cell-free assay)
50 nM 100 nM
體外研究(In Vitro)
體外研究活性

SB 202190顯著抑制內(nèi)源本底和和抗Fas抗體誘導(dǎo)的MAPKAPK 2活性，且抑制效果呈劑量依賴性。SB 202190本身就足以誘導(dǎo)Jurkat細(xì)胞和Hela細(xì)胞的死亡：通過激活CPP 32樣半胱氨酸蛋白酶，可阻斷Bcl - 2的表達(dá)。p38β可減輕而p38α可加劇由SB 202190誘導(dǎo)的細(xì)胞凋亡[2]。在HaCaT細(xì)胞中SB 202190強(qiáng)烈抑制由紫外線誘導(dǎo)的cox - 2蛋白表達(dá)和 mRNA水平[3]。用SB 202190處理腎小管上皮細(xì)胞（正常大鼠k肝臟-52E），可將由白蛋白引發(fā)的炎癥（單核細(xì)胞趨化蛋白-1，MCP - 1）或腫瘤生長(zhǎng)因子β-1（TGFβ-1）引發(fā)的原纖維化（原骨膠原I a1，procollagen-i alpha1）相關(guān)基因降低50%[4]。SB 202190處理A549細(xì)胞，可誘導(dǎo)JNK磷酸化（該磷酸化效應(yīng)呈時(shí)間和劑量依賴性）、轉(zhuǎn)錄因子ATF - 2磷酸化，并增加AP – 1與DNA的結(jié)合[6]。SB 202190處理促進(jìn)THP-1和MV4-11細(xì)胞的生長(zhǎng)。SB 202190可提高c-Raf 和ERK（細(xì)胞外信號(hào)調(diào)節(jié)激酶）磷酸化，暗示由SB 202190誘導(dǎo)的白血病細(xì)胞增殖過程有Ras-Raf-MEK-mitogen激活的MAPK通路的參與[7]。
激酶實(shí)驗(yàn) 體外酶活檢測(cè)
p38α 和 p38β 溶解在25mM的Tris - HCl緩沖液中，PH 7.5，含0.1mM EGTA，髓鞘堿性蛋白（0.33毫克/毫升）作為底物。人工操作條件用50μL [γ-33P]ATP于30 °C孵育10分鐘；Biomek 2000自動(dòng)化工作站用25μL [γ-33P]ATP在96孔板室溫孵育40分鐘。ATP和乙酸鎂濃度分別為0.1mM和10mM。所有檢測(cè)都用MgATP起始。人工檢測(cè)將孵育液滴到磷酸纖維素紙上，浸泡在50mM磷酸中。用5μL磷酸終止反應(yīng)，后將孵育液點(diǎn)滴在P30過濾墊上。濾膜在50mM磷酸中漂洗四次以去除ATP，在用丙酮（人工孵育）或甲醇（工作站孵育）處理后，干燥并用放射性計(jì)量。
細(xì)胞實(shí)驗(yàn) 細(xì)胞系 Jurkat, 和 HeLa細(xì)胞
濃度 溶解于DMSO, 終濃度~50 μM
孵育時(shí)間 24 小時(shí)
方法

細(xì)胞血清饑餓后，用不同濃度SB 202190處理24小時(shí)。用臺(tái)盼藍(lán)或PI染色后經(jīng)流式細(xì)胞儀分析，以檢測(cè)細(xì)胞活力。凋亡細(xì)胞核用H33258染色。
實(shí)驗(yàn)圖片 檢測(cè)方法 檢測(cè)指標(biāo) 實(shí)驗(yàn)圖片 PMID
Western blot mTOR / p-S6K / S6K / p-S6 / p-AKT / p-MK2 pJNK1 / pJNK2 / JNK1 / JNK2 26844273
Immunofluorescence p-p38 / MMP9 24479681
Growth inhibition assay Cell viability 26844273
體內(nèi)研究(In Vivo)
體內(nèi)研究活性

SB 202190通過抑制p38減弱了由人脊髓灰質(zhì)炎IgG（PV-IgG）在被動(dòng)轉(zhuǎn)移小鼠模型中誘發(fā)的水泡形成[5]。在膿毒癥內(nèi)毒素模型中，與對(duì)照組相比，經(jīng)SB 202190處理可顯著提高存活率[8]。
動(dòng)物實(shí)驗(yàn) Animal Models C57BL/6J 小鼠皮內(nèi)注射無菌的對(duì)照IgG或人脊髓灰質(zhì)炎IgG做對(duì)比。
Dosages 12.5 μg
Administration 皮內(nèi)注射

化學(xué)信息&溶解度

分子量 331.34 分子式

C20H14N3OF
CAS號(hào) 152121-30-7 SDF Download SB202190 SDF
Smiles C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

DMSO : 66 mg/mL ( (199.19 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Ethanol : 22 mg/mL (66.39 mM)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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