成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Glycyrrhizin (NSC 167409)

中文名稱：甘草酸，甘草甜素

Glycyrrhizin (NSC 167409, Glycyrrhizic Acid)是一種直接的高遷移率族蛋白1(HMGB1)的抑制劑，抑制依賴于HMGB1的炎癥分子表達(dá)和氧化應(yīng)激反應(yīng)。調(diào)節(jié)p38和p-JNK信號(hào)通路，而不影響p-ERK信號(hào)通路。同時(shí)也能抑制11 beta-hydroxysteroid dehydrogenase。

Glycyrrhizin (NSC 167409) Chemical Structure

Glycyrrhizin (NSC 167409) Chemical Structure

CAS: 1405-86-3

規(guī)格 價(jià)格 庫(kù)存 購(gòu)買數(shù)量
10mM (1mL in DMSO) 794.43 現(xiàn)貨
10mg 563.71 現(xiàn)貨
100mg 3049.11 現(xiàn)貨
1g 7944.3 現(xiàn)貨
更大包裝 有超大折扣

400-668-6834

info@selleck.cn
免費(fèi)分裝
免費(fèi)預(yù)溶

Glycyrrhizin (NSC 167409)相關(guān)產(chǎn)品

相關(guān)信號(hào)通路圖

Dehydrogenase Signaling Pathways

Dehydrogenase信號(hào)通路圖

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
Vero E6 Antiviral assay 10 uM 96 hrs Antiviral activity against DENV2 16681 infected in African green monkey Vero E6 cells assessed as reduction in virus induced cytopathic effect at 10 uM measured after 96 hrs by reverse phase contrast microscopy 31519375
RAW264.7 Anti-inflammatory assay 40 uM 2 hrs Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 40 uM preincubated for 2 hrs followed by LPS addition measured after 20 hrs by Griess assay relative to control ChEMBL
RAW264.7 Anti-inflammatory assay 10 to 40 uM 2 hrs Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production at 10 to 40 uM preincubated for 2 hrs followed by LPS addition measured after 20 hrs by ELISA ChEMBL
HEK293 Function assay 60 mins Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA, EC50=0.001μM. 22440625
HEK293 Function assay 60 mins Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA, EC50=0.008μM. 22440625
HEK293 Function assay 60 mins Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA, EC50=0.01μM. 22440625
MDCK Cytotoxicity assay 48 hrs Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs by MTT assay, EC50=15.2μM. 25801933
MDCK Antiviral assay 15 mins Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in dog MDCK cells preincubated with virus for 15 mins followed by cells addition measured at 36 hrs post infection, IC50=39.6μM. 26841168
Vero E6 Antiviral assay 96 hrs Antiviral activity against DENV2 16681 infected in African green monkey Vero E6 cells assessed as inhibitory rate of NS4B positive cells measured after 96 hrs incubation by DAPI staining based immunofluorescence method, IC50=8.1μM. 31519375
HEK293 Function assay Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay, IC50=0.001μM. 19564108
HEK293 Function assay Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay, IC50=0.008μM. 19564108
HEK293 Function assay Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay, IC50=0.01μM. 19564108
HEK293 Function assay Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay, IC50=0.015μM. 19574056
HEK293 Function assay Inhibition of human 11beta-HSD2 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay, IC50=0.0007μM. 22148241
HEK293 Function assay Inhibition of human 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay, IC50=0.0186μM. 22148241
HEK293 Function assay Inhibition of mouse 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay, IC50=0.0295μM. 22148241
HEK293 Function assay Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay, IC50=0.0004μM. 22360639
HEK293 Function assay Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay, IC50=0.003μM. 22360639
HEK293 Function assay Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay, IC50=0.006μM. 22360639
MDCK Antiviral assay Antiviral activity against influenza A virus (A/California/07/09(H1N1)) pdm09 infected in MDCK cells assessed as decrease in virus titer by hemagglutination assay in presence of 1% suspension of chicken erythrocytes, CD50=47.5μM. 25801933
Raji Antiviral assay Antiviral activity against EBV infected in human Raji cells assessed as reduction in viral genome copy numbers by qRT-PCR analysis, EC50=30μM. 30731401
點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù)

生物活性

產(chǎn)品描述 Glycyrrhizin (NSC 167409, Glycyrrhizic Acid)是一種直接的高遷移率族蛋白1(HMGB1)的抑制劑，抑制依賴于HMGB1的炎癥分子表達(dá)和氧化應(yīng)激反應(yīng)。調(diào)節(jié)p38和p-JNK信號(hào)通路，而不影響p-ERK信號(hào)通路。同時(shí)也能抑制11 beta-hydroxysteroid dehydrogenase。
靶點(diǎn)
11 beta-hydroxysteroid dehydrogenase [1] HMGB1 [2] MAO [4]
(Cell-free)
0.16 μM
體外研究(In Vitro)
體外研究活性

Glycyrrhizin抑制單胺氧化酶（MAO），IC50為0.16 μM[4]。
體內(nèi)研究(In Vivo)
體內(nèi)研究活性

Glycyrrhizin在小鼠的大腦中增加單胺類如epinephrine和dopamine的水平[3]。

化學(xué)信息&溶解度

分子量 822.93 分子式

C42H62O16
CAS號(hào) 1405-86-3 SDF Download Glycyrrhizin (NSC 167409) SDF
Smiles CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

DMSO : 100 mg/mL ( (121.51 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

技術(shù)支持

在訂購(gòu)、運(yùn)輸、儲(chǔ)存和使用我們的產(chǎn)品的任何階段，您遇到的任何問(wèn)題，均可以通過(guò)撥打我們的熱線電話400-668-6834，或者技術(shù)支持郵箱tech@selleck.cn，直接聯(lián)系到我們。我們會(huì)在24小時(shí)內(nèi)盡快聯(lián)系您。

操作手冊(cè)

如果有其他問(wèn)題，請(qǐng)給我們留言。

* 必填項(xiàng)

請(qǐng)輸入您的姓名
請(qǐng)輸入您的郵箱地址 請(qǐng)輸入一個(gè)有效的郵箱地址
請(qǐng)寫點(diǎn)東西給我們
Tags: buy Glycyrrhizin (NSC 167409) | Glycyrrhizin (NSC 167409) supplier | purchase Glycyrrhizin (NSC 167409) | Glycyrrhizin (NSC 167409) cost | Glycyrrhizin (NSC 167409) manufacturer | order Glycyrrhizin (NSC 167409) | Glycyrrhizin (NSC 167409) distributor
在線咨詢
聯(lián)系我們