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  2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Endogenous Metabolite Parasite Apoptosis
  4. Linolelaidic acid

Linolelaidic acid  (Synonyms: 亞麻酸; Linoelaidic acid)

目錄號: HY-W071746 純度: 99.52%
COA 產(chǎn)品使用指南 技術(shù)支持

Linolelaidic acid (Linoelaidic acid) 屬于 omega-6 反式脂肪酸 (TFA)，是一種具有口服活性的人體必需營養(yǎng)素，可添加于腸內(nèi)營養(yǎng)制劑 (口服)、腸外營養(yǎng)制劑 (靜脈注射) 以及嬰兒配方食品中。Linolelaidic acid 具有抗炎和抗寄生蟲 (Parasite) 活性，并且可以誘導(dǎo)細(xì)胞凋亡 (Apoptosis)。Linolelaidic acid 可用于感染領(lǐng)域研究。

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Linolelaidic acid Chemical Structure

Linolelaidic acid Chemical Structure

CAS No. : 506-21-8

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
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50 mg ￥500
In-stock
100 mg ￥800
In-stock
200 mg   詢價  
500 mg   詢價  

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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Linolelaidic acid (Linoelaidic acid) is an omega-6 trans fatty acid (TFA) that is an essential nutrient with oral activity. Linolelaidic acid can be added to enteral nutrition (oral), parenteral nutrition (intravenous), and infant formula. Linolelaidic acid has anti-inflammatory and anti-parasitic ((Parasite)) activities, and can induce Apoptosis. Linolelaidic acid is useful for research in infections[1][2][3].

體外研究
(In Vitro)

Linolenic Acid 對 P. falciparum D10 株(氯喹敏感株) 和 Dd2 株 (氯喹耐藥株) 具有抑制活性，IC50 分別為 4.12 μg/mL 和 5.04 μg/mL[2]。
Linolelaidic acid (50 μM, 24 小時) 通過脂筏誘導(dǎo)人臍靜脈內(nèi)皮細(xì)胞的凋亡、細(xì)胞周期停滯和炎癥[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration: 50 μM
Incubation Time: 24 h
Result: Resulted in a significant decrease in cell viability.

Apoptosis Analysis[3]

Cell Line: Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration: 50 μM
Incubation Time: 24 h
Result: Resulted in a significant increase in the number of apoptotic cells and the cell population in the G1 phase.

Western Blot Analysis[3]

Cell Line: Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration: 50 μM
Incubation Time: 24 h
Result: Led to a significant increase in the expression levels of pro-apoptotic proteins (caspase-3, -8, Bax, p53) and inflammatory factors (vascular cell adhesion molecule-1, intercellular adhesion molecule, E-selectin, and nitric oxide), while the expression level of the anti-apoptotic protein Bcl-2 was significantly decreased.
體內(nèi)研究
(In Vivo)

Linolenic Acid (10 mg/kg，口服，每日一次，連續(xù) 4 天) 在 P. berghei (ANKA) 株誘導(dǎo)的瘧疾 C57BL/6 小鼠模型中表現(xiàn)出抗寄生蟲活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. berghei (ANKA) strain-induced malaria C57BL/6 mice model (7-to-10-week old)[3]
Dosage: 10 mg/kg
Administration: Oral gavage (p.o.), once daily for 4 days
Result: Inhibited the growth of P. berghei by 70%.
Animal Model: High-fat diet-fed streptozotocin (HFD-STZ) rat model[2]
Dosage: 500 μg/kg
Administration: Oral gavage (p.o.), once daily for 4 weeks, 30 min myocardial ischemia followed by 4 or 6 h reperfusion after 4 weeks
Result: Significantly improved the instantaneous first derivation of left ventricle pressure, reduced infarct size, plasma creatine kinase and lactate dehydrogenase activities, and apotosis at the end of reperfusion in HFD-STZ diabetic rats.
Not only significantly reduced tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) concentrations but reduced the increase in superoxide production and malonaldialdehyde formation and simultaneously enhanced the antioxidant capacity in the diabetic hearts.
Increased myocardial PI3K expression and Akt phosphorylation in diabetic but not normal rats.
分子量

280.45

Formula

C18H32O2
CAS 號
性狀

液體（密度：0.89 g/cm3）

顏色

Colorless to light yellow

中文名稱

亞麻酸
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 125 mg/mL (445.71 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.5657 mL 17.8285 mL 35.6570 mL
5 mM 0.7131 mL 3.5657 mL 7.1314 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請?jiān)?個月內(nèi)使用，-20°C儲存時，請?jiān)?個月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計(jì)算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.52%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請?jiān)?個月內(nèi)使用，-20°C儲存時，請?jiān)?個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5657 mL 17.8285 mL 35.6570 mL 89.1424 mL
5 mM 0.7131 mL 3.5657 mL 7.1314 mL 17.8285 mL
10 mM 0.3566 mL 1.7828 mL 3.5657 mL 8.9142 mL
15 mM 0.2377 mL 1.1886 mL 2.3771 mL 5.9428 mL
20 mM 0.1783 mL 0.8914 mL 1.7828 mL 4.4571 mL
25 mM 0.1426 mL 0.7131 mL 1.4263 mL 3.5657 mL
30 mM 0.1189 mL 0.5943 mL 1.1886 mL 2.9714 mL
40 mM 0.0891 mL 0.4457 mL 0.8914 mL 2.2286 mL
50 mM 0.0713 mL 0.3566 mL 0.7131 mL 1.7828 mL
60 mM 0.0594 mL 0.2971 mL 0.5943 mL 1.4857 mL
80 mM 0.0446 mL 0.2229 mL 0.4457 mL 1.1143 mL
100 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.8914 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Linolelaidic acid
目錄號：
HY-W071746
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