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  2. Anti-infection Metabolic Enzyme/Protease NF-κB Cell Cycle/DNA Damage
  3. Parasite Tyrosinase NF-κB CDK
  4. Kojic acid

Kojic acid  (Synonyms: 曲酸)

目錄號: HY-W050154 純度: 99.99%
COA 產(chǎn)品使用指南

Kojic acid 是由 Aspergillus oryzae 產(chǎn)生的物質(zhì)，具有口服有效性，也可被透皮吸收。Kojic acid 具有抗衰老、抗線蟲、抗菌、抗氧化、抗炎等多種生物活性。Kojic acid 是Tyrosinase抑制劑，對 Mushroon Tyrosinase IC50 為 182.7 μM。Kojic acid 通過捕獲與酪氨酸酶活性位點結(jié)合的銅離子防止其激活來阻止黑色素產(chǎn)生。Kojic acid 對人角質(zhì)形成細(xì)胞中 NF-κB 和 p21 信號通路具有抑制作用。Kojic acid 衍生物具有抗腫瘤活性。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

Kojic acid Chemical Structure

Kojic acid Chemical Structure

CAS No. : 501-30-4

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
In-stock
1 g ￥200
In-stock
5 g ￥400
In-stock
10 g   詢價  
50 g   詢價  

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Other Forms of Kojic acid:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity[1][2][3][4][5][6][7][8].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 GI50
> 100 μM
Compound: 1; KA
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 35114540]
B16 IC50
> 50 μM
Compound: Kojic acid
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 48 hrs
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 48 hrs
[PMID: 20149498]
B16 IC50
> 500 μM
Compound: Kojic acid
Inhibition of alpha-MSH-stimulated melanin production in mouse B16 cells after 72 hrs by microplate reader analysis
Inhibition of alpha-MSH-stimulated melanin production in mouse B16 cells after 72 hrs by microplate reader analysis
[PMID: 26706112]
B16 IC50
111 μM
Compound: Kojic acid
Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days
Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days
[PMID: 19524439]
B16 IC50
15.8 μM
Compound: Kojic acid
Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs by spectrometric analysis
Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs by spectrometric analysis
[PMID: 21978680]
B16 IC50
39 μM
Compound: Kojic acid
Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry
Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry
[PMID: 23623417]
B16 IC50
5.5 μg/mL
Compound: Kojic acid
Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs
Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs
[PMID: 22450129]
B16 IC50
70 μM
Compound: Kojic acid
Antimelanogenic activity at alpha-MSH-stimulated mouse melanoma B16 cells after 3 days by spectrophotometry
Antimelanogenic activity at alpha-MSH-stimulated mouse melanoma B16 cells after 3 days by spectrophotometry
[PMID: 22217872]
B16 IC50
70 μM
Compound: Kojic acid
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 3 days
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 3 days
[PMID: 21601449]
B16 IC50
70 μM
Compound: kojic acid
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs
[PMID: 20097083]
B16 IC50
70 μM
Compound: Kojic acid
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs
[PMID: 20044259]
B16-F10 IC50
144.4 μM
Compound: 1a; KA
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability by MTT assay
[PMID: 32652434]
B16-F10 IC50
500 μM
Compound: Kojic acid
Antimelanogenic activity in mouse B16F10 cells assessed as inhibition of melanin production after 4 days
Antimelanogenic activity in mouse B16F10 cells assessed as inhibition of melanin production after 4 days
[PMID: 25597012]
B16-F10 IC50
84.54 μM
Compound: Kojic acid
Inhibition of alpha-MSH-induced melanogenesis in mouse B16F10 cells after 3 days by spectrophotometric analysis
Inhibition of alpha-MSH-induced melanogenesis in mouse B16F10 cells after 3 days by spectrophotometric analysis
[PMID: 23063404]
BV-2 IC50
> 500 μM
Compound: KA
Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 36846369]
G-361 IC50
571.17 μM
Compound: Kojic acid
Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometry
Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometry
[PMID: 25288494]
H9c2 IC50
> 500 μM
Compound: KA
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 36846369]
HEK293 IC50
2 μM
Compound: 6a, Kojic acid
Inhibition of human recombinant DAAO expressed in HEK293 cell lysate assessed as D-Serine conversion to H2O2 after 20 mins by spectrophotometric analysis
Inhibition of human recombinant DAAO expressed in HEK293 cell lysate assessed as D-Serine conversion to H2O2 after 20 mins by spectrophotometric analysis
[PMID: 23683589]
HFF IC50
> 150 μM
Compound: 1a; KA
Cytotoxicity against human HFF cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human HFF cells assessed as reduction in cell viability by MTT assay
[PMID: 32652434]
HT-22 IC50
> 500 μM
Compound: KA
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 36846369]
L02 IC50
> 500 μM
Compound: KA
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 36846369]
Melan-a IC50
1.6 mM
Compound: 1
Depigmentation activity in mouse Melan-a cells assessed as inhibition of melanin formation after 4 days
Depigmentation activity in mouse Melan-a cells assessed as inhibition of melanin formation after 4 days
[PMID: 22071299]
Melan-a IC50
1.64 mM
Compound: 1, Kojic acid
Depigmentation activity in mouse Melan-a cells after 4 days by spectrophotometry
Depigmentation activity in mouse Melan-a cells after 4 days by spectrophotometry
[PMID: 22579419]
Melan-a IC50
3.5 mM
Compound: 1
Cytotoxicity against mouse Melan-a cells by modified crystal voilet assay
Cytotoxicity against mouse Melan-a cells by modified crystal voilet assay
[PMID: 22071299]
Melan-a IC50
3.53 mM
Compound: 1, Kojic acid
Cytotoxicity against mouse Melan-a cells after 4 days by crystal voilet method
Cytotoxicity against mouse Melan-a cells after 4 days by crystal voilet method
[PMID: 22579419]
RAW264.7 IC50
> 100 μM
Compound: 1
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 20934336]
RAW264.7 IC50
89.41 μM
Compound: 1
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated for 30 mins before LPS challenge measured after 24 hrs by Griess reagent method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated for 30 mins before LPS challenge measured after 24 hrs by Griess reagent method
[PMID: 20934336]
SH-SY5Y IC50
> 500 μM
Compound: KA
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 36846369]
體外研究
(In Vitro)

Kojic acid (1000 μM，7 天) 增強(qiáng) HCEC 細(xì)胞的細(xì)胞遷移能力，并對其具有抗衰老活性[1]。
Kojic acid (1000 μM, 7 天) 可能通過 NF-κB 和 p21 信號通路緩解由衰老的 HCEC 細(xì)胞的上清液誘導(dǎo)的人臍靜脈內(nèi)皮細(xì)胞 (HUVEC) 血管生成[1]。
Kojic acid (1.4-1000 μg/mL，3天) 對 M. incognita 表現(xiàn)出劑量依賴性的致死率和孵化抑制率，EC50 分別為 195.2 μg/mL 和 238.3 μg/mL[4]。
Kojic acid (1000 μM，2-6 天) 以濃度依賴的方式抑制 B16-4A5 細(xì)胞和 HMV-II 細(xì)胞中的黑色素生成[6]。
Kojic acid (500 或 1000 μM，72 小時) 降低了 B16-4A5 細(xì)胞 HMV-II 細(xì)胞中和酪氨酸酶表達(dá)，表明 Kojic acid 由于抑制酪氨酸酶活性而抑制黑色素生成[6]。
Kojic acid (10-2500 μM，7 天) 對 HCEC 細(xì)胞活力無顯著影響[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCEC-B4G12?cells (human corneal endothelial cell line)
Concentration: 10, 100?, 1000, 2500, 5000 μM
Incubation Time: 7 days
Result: Did not influence the cell viability of HCEC after 7 days' treatment at 10-2500?μM but decreased the cell viability a little bit at 5000?μM.

Cell Migration Assay [1]

Cell Line: HCEC-B4G12?cells (human corneal endothelial cell line)
Concentration: 1000 μM
Incubation Time: 7 days
Result: Delayed the reduction in cell migration ability caused by aging in HCEC cells.

Western Blot Analysis[1]

Cell Line: HCEC-B4G12?cells (human corneal endothelial cell line)
Concentration: 1000 μM
Incubation Time: 7 days
Result: Inhibited the abnormal high expression of galectin 8, laminin α1, laminin α2, laminin γ1, and p21 in senescent HCEC, as well as the significant decrease in p-NF-κB protein expression.
體內(nèi)研究
(In Vivo)

Kojic acid (50 mg/kg，口服，1 天 1 次連續(xù) 3 周) 對 β-Amyloid (1-42), human (HY-P1363A) 誘導(dǎo)的阿爾茲海默癥小鼠模型具有抗氧化和抗炎活性[8]。
Kojic acid (4, 6.4, 10, 16 g/kg, 口服, 單次給藥) 在急性口服實驗中對 JCL-Wistar 大鼠的毒性較小[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: β-Amyloid (1-42), human (HY-P1363A)-Induced Mouse Model of Alzheimer's Disease[8]
Dosage: 50 mg/kg
Administration: Oral gavage, once daily for 3 weeks
Result: Ameliorated β-Amyloid (1-42), human (HY-P1363A)-induced glial cell activation and reduced inflammatory markers in the hippocampus.
Reduced ROS and lipid peroxidase levels in Alzheimer's Disease mice model
Animal Model: JCL-Wistar rats[2]
Dosage: 4, 6.4, 10, 16 g/kg
Administration: Oral gavage (p.o.),single dose
Result: Had an oral LD50 in rats greater than 2 g/kg in acute toxicity studies[2].
分子量

142.11

Formula

C6H6O4
CAS 號
性狀

固體

顏色

Off-white to light yellow

中文名稱

曲酸
結(jié)構(gòu)分類
初始來源

Aspergillus, Penicillium or Acetobacter spp
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : ≥ 100 mg/mL (703.68 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

H2O 中的溶解度 : 50 mg/mL (351.84 mM; 超聲助溶)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 7.0368 mL 35.1840 mL 70.3680 mL
5 mM 1.4074 mL 7.0368 mL 14.0736 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

請根據(jù)您的 實驗動物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 5 mg/mL (35.18 mM); 懸濁液; 超聲助溶

    此方案可獲得 5 mg/mL的均勻懸濁液，懸濁液可用于口服和腹腔注射。

    以 1 mL 工作液為例，取 100 μL 50.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (17.59 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： PBS

    Solubility: 14.29 mg/mL (100.56 mM); 澄清溶液; 超聲助溶 (<60°C)

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.99%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 7.0368 mL 35.1840 mL 70.3680 mL 175.9201 mL
5 mM 1.4074 mL 7.0368 mL 14.0736 mL 35.1840 mL
10 mM 0.7037 mL 3.5184 mL 7.0368 mL 17.5920 mL
15 mM 0.4691 mL 2.3456 mL 4.6912 mL 11.7280 mL
20 mM 0.3518 mL 1.7592 mL 3.5184 mL 8.7960 mL
25 mM 0.2815 mL 1.4074 mL 2.8147 mL 7.0368 mL
30 mM 0.2346 mL 1.1728 mL 2.3456 mL 5.8640 mL
40 mM 0.1759 mL 0.8796 mL 1.7592 mL 4.3980 mL
50 mM 0.1407 mL 0.7037 mL 1.4074 mL 3.5184 mL
60 mM 0.1173 mL 0.5864 mL 1.1728 mL 2.9320 mL
80 mM 0.0880 mL 0.4398 mL 0.8796 mL 2.1990 mL
100 mM 0.0704 mL 0.3518 mL 0.7037 mL 1.7592 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Kojic acid
目錄號：
HY-W050154
需求量：