Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.

fungal

The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine. [³H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC₅₀=1.2 μM) or melarsen oxide (IC₅₀=0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC₅₀=6.1 μM) and Stilbamidine (IC₅₀=110 μM)^[1]. The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

264.33

C₁₆H₁₆N₄

122-06-5

司替巴脒

Room temperature in continental US; may vary elsewhere.

• [1]. De Koning HP. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Mol Pharmacol. 2001 Mar;59(3):586-92.  [Content Brief]

  [2]. BREWER AE.et al. Multiple myeloma treated with stilbamidine and pentamidine. Br Med J. 1948 Dec 4;2(4587):978-82.  [Content Brief]