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  2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Antibody-Drug Conjugates (ADCs) EGFR
  4. Disitamab vedotin

Disitamab vedotin  (Synonyms: 維迪西妥單抗; RC48)

目錄號: HY-P9985 純度: ≥99.0%
COA 產(chǎn)品使用指南

Disitamab vedotin (RC48) 是一種抗體-活性分子偶聯(lián)物 (ADC)，包含抗人表皮生長因子受體2 (HER2) 的單克隆抗體，該單克隆抗體通過可降解連接子結(jié)合到細胞毒性劑 MMAE。Disitamab vedotin 增強抗腫瘤免疫。

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Disitamab vedotin Chemical Structure

Disitamab vedotin Chemical Structure

CAS No. : 2136633-23-1

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥3400
In-stock
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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity[1].

IC50 & Target[1]

HER2

 

體外研究
(In Vitro)

The antibody part was a humanized monoclonal antibody targeting HER2, the small molecule toxin was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease cleavable linker covalently attached MMAE to the antibody[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

149000 (average)

CAS 號
性狀

固體

顏色

White to light yellow

中文名稱

維迪西妥單抗
運輸條件

Shipping with dry ice.
儲存方式

-80°C, protect from light
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Disitamab vedotin
目錄號：
HY-P9985
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