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  2. Immunology/Inflammation
  3. Interleukin Related
  4. Reslizumab

Reslizumab  (Synonyms: 瑞利珠單抗; Sch 55700)

目錄號(hào): HY-P9949 純度: 99.4%
COA

Reslizumab (Sch 55700) 是靶向人白介素 5 (IL-5) 的人源化單克隆抗體，用于研究嗜酸性粒細(xì)胞性哮喘。Reslizumab 可有效阻斷 IL-5 的功能。Reslizumab 對(duì)人 IL-5 具有高結(jié)合親和力，在 Biacore 表面等離振子共振和動(dòng)力學(xué)排斥分析中，KD 值分別為 109 pM 和 4.3 pM。

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CAS No. : 241473-69-8

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1 mg ￥10000
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with KD values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively[1][2].

同型

Human IgG4 kappa
推薦同型對(duì)照抗體
種屬

Humanized
IC50 & Target[1][2]

IL-5

91.1 pM (IC50)

體外研究
(In Vitro)

Reslizumab (Sch 55700) (0-10 nM, 48 h) inhibits IL-5-dependent cell proliferation, with an IC50 value of approximately 91.1pM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Human erythroleukemic TF-1 cell line
Concentration: 0-10 nM
Incubation Time: 48 h
Result: Showed antiproliferative activity with an IC50 of 91.1 pM.
體內(nèi)研究
(In Vivo)

Reslizumab (Sch 55700) (0-10 mg/kg; i.p. or i.m.) inhibits pulmonary eosinophilia in a dose-dependent manner in allergic mice[3].
Reslizumab (0.03-30 mg/kg; i.p.) inhibits both the pulmonary eosinophilia and airway hyperresponsiveness, and at 30 mg/kg, i.p. inhibits allergic, but not histamine-induced bronchoconstriction in allergic guinea pigs[3].
Reslizumab (0.1-1 mg/kg; i.p.) blocks the pulmonary eosinophilia and neutrophilia caused by tracheal injection of hIL-5 in guinea pigs[3].
Reslizumab (0.3 mg/kg; i.v.) blocks the pulmonary eosinophilia caused by antigen challenge for up to six months in allergic cynomolgus monkeys[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male B6D2F1/J mice weighing 20?25 g, sensitized by an intraperitoneal injection of 0.5 ml of alum-precipitated antigen (8 μg of ovalbumin (OVA) adsorbed to 2 mg of aluminum hydroxide gel in saline vehicle)[3]
Dosage: 0?10 mg/kg
Administration: Intraperitoneal or intramuscular injection (For studies involving i.p. dose-response and i.m. evaluation, the antibody was given 2 h before OVA challenge. For experiments involving duration of activity, the antibody was given at times of 2 h or 4, 6, 8 or 12 weeks before antigen challenge.)
Result: Inhibited the influx of eosinophils into the lungs for a long time (up to 8 weeks after administration of 10 mg/kg and for up to 4 weeks after administration of 2 mg/kg. Demonstrated an anti-inflammatory activity that was additive to that of oral Prednisolone (HY-17463).
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱(chēng)

瑞替珠單抗； 瑞利珠單抗
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
純度 & 產(chǎn)品資料

純度: 99.4%

參考文獻(xiàn)

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  • 稀釋計(jì)算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Reslizumab
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HY-P9949
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