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  2. Apoptosis Anti-infection
  3. TNF Receptor Bacterial
  4. Adalimumab

Adalimumab  (Synonyms: 阿達(dá)木單抗; Anti-Human TNF-alpha, Human Antibody)

目錄號(hào): HY-P9908 純度: 99.25%
COA

Adalimumab 是一種人源的單克隆 IgG1 抗體，靶向腫瘤壞死因子α (TNF-α)。

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CAS No. : 331731-18-1

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2700
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5 mg ￥5700
In-stock
10 mg ￥8835
In-stock
25 mg 詢價(jià)
50 mg 詢價(jià)

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  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor?α (TNF-α).

IC50 & Target

TNF-α[1]
體外研究
(In Vitro)

使用 Adalimumab 處理 HUVEC 長達(dá) 12 小時(shí)，顯示對(duì)其細(xì)胞活力沒有不利影響，即使 Adalimumab 的濃度比本研究中使用的濃度高 10 倍[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Adalimumab 的消除半衰期很長 (t1/2=~20 天)[1]。
熒光標(biāo)記的 Adalimumab 富集主要在油紅 O 陽性病變中觀察到，證明藥物進(jìn)入動(dòng)脈粥樣硬化斑塊的良好組織滲透性，在溶劑對(duì)照注射到高膽固醇血癥 Ldlr-/- 老鼠后，血管壁無背景熒光[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

阿達(dá)木單抗；阿達(dá)莫單抗
運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded TNF-alpha/TNFSF2 Protein, Human (177a.a, His, HY-P700291) on AHC2 biosensor, can bind Adalimumab with an affinity constant of 2.247E-10 M as determined in BLI assay.
  • Immobilized TNF-alpha/TNFSF2 Protein, Human (HY-P7058) can bind Adalimumab. The EC50 for this effect is 6.753 ng/mL.
純度 & 產(chǎn)品資料

純度: 99.62%

參考文獻(xiàn)
Cell Assay
[2]

1×104 HUVECs are plated per well of 96 well plate in EGM. After reaching sub-confluency cells are cultured in different concentration of Adalimumab (0.01-10 μg/mL), IgG isotype control (10 μg/mL) and 0.1% Triton-X as positive control in 5% CO2 at 37°C. After 12 hours, 10% Alamar blue is added to each well and kept in incubator for another 6 hours. Absorbance of oxidized alamar blue is measured at 600 nm on Infinite M200 pro plate reader. All measurements are performed in triplicate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Mice[2]
In order to analyze the vascular distribution of Adalimumab, the substance is labelled using the DyLight 549 Microscale Antibody Labeling Kit. Briefly, one vial of DyLight 549 Reagent is dissolved in 1 mg Adalimumab solution (in PBS) and purified with a resin spin column to remove excess fluor. Hypercholesterolemic Ldlr-/- mice are injected with fluorophore-labelled Adalimumab (8.0 mg/kg in 200 μL PBS i.p.) for two consecutive days and sacrificed 12 hours after last injection. Vehicle injection (200 μL PBS) is used as control.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Adalimumab
目錄號(hào)：
HY-P9908
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