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  2. 多肽產(chǎn)品
  3. 多肽及其衍生物
  4. 抑制劑與底物肽
  5. LCKLSL

LCKLSL 是一種 N 末端六肽，是一種競爭性的膜聯(lián)蛋白 A2 (AnxA2) 抑制劑，可有效抑制組織纖溶酶原激活物 (tPA) 與 AnxA2 的結(jié)合。LCKLSL 還可抑制纖溶酶的產(chǎn)生，并具有抗血管生成的作用。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Custom Peptide Synthesis

LCKLSL Chemical Structure

LCKLSL Chemical Structure

CAS No. : 533902-29-3

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1 mg ￥1000
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5 mg ￥2500
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10 mg ￥4500
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Customer Review

Other Forms of LCKLSL:

    LCKLSL purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 Mar;159:114173.  [Abstract]

    LCKLSL (5 μM) intervention significantly inhibits ANXA2 protein expression levels when compare to the alcohol group, in activated HSC-T6 cells.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].

    IC50 & Target

    Annexin A2 (AnxA2)[1]
    體外研究
    (In Vitro)

    In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    675.88

    Formula

    C30H57N7O8S
    CAS 號(hào)
    性狀

    固體

    顏色

    White to off-white

    Sequence

    Leu-Cys-Lys-Leu-Ser-Leu
    Sequence Shortening

    LCKLSL
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    純度 & 產(chǎn)品資料
    參考文獻(xiàn)

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量   濃度   體積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    產(chǎn)品名稱：
    LCKLSL
    目錄號(hào)：
    HY-P2333
    需求量：