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  2. Immunology/Inflammation Anti-infection
  3. Complement System SARS-CoV
  4. AMY-101

AMY-101 (Cp40) 是補(bǔ)體 C3 的肽類抑制劑 (KD = 0.5 nM)，可抑制非人類靈長類動物自然發(fā)生的牙周炎。AMY-101 (Cp40) 在 COVID-19 重癥肺炎合并全身超炎癥模型中具有良好的抗炎活性。

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AMY-101 Chemical Structure

AMY-101 Chemical Structure

CAS No. : 1427001-89-5

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3.  試用裝只面向終端客戶。

規(guī)格 是否有貨
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100 mg   詢價  
250 mg   詢價  

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AMY-101 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of AMY-101:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].

IC50 & Target

KD: 0.5 nM (C3)[1].
體內(nèi)研究
(In Vivo)

AMY-101可改善自然慢性牙周炎NHPs的牙周狀況[1]。
AMY-101可誘導(dǎo)長效抗炎作用[1]。
AMY-101 (4 mg/kg 體重，皮下注射。每 24 小時一次，共 28 天) 導(dǎo)致 PPD 顯著和持久減少，PPD 是衡量組織破壞的指標(biāo)[1]。
AMY-101 (Cp40，1 mg/kg，sc，每 12 小時注射一次，每天一次，7 或 14 天) 減輕 UUO 誘導(dǎo)的腎臟纖維化和炎性細(xì)胞浸潤纖維化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight)[1].
Dosage: 0.1 mg/site; 50 μL of 2 mg/mL solution.
Administration: Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.)
Result: Does not cause irritation in healthy gingiva.
Animal Model: UUO and sham-operated mice[3].
Dosage: 1 mg/kg.
Administration: Subcutaneous injection every 12 h, daily, 7 or 14 days.
Result: 1 mg/kg Cp40 had much less severe interstitial fibrosis than control peptide-injected mice.
Clinical Trial
分子量

1789.09

Formula

C83H117N23O18S2
CAS 號
Sequence

Tyr-Ile-Cys-Val-{Trp(Me)}-Gln-Asp-Trp-{Sar}-Ala-His-Arg-Cys-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)
Sequence Shortening

YICV-{Trp(Me)}-QDW-{Sar}-AHRC-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
細(xì)胞實(shí)驗(yàn)： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
AMY-101
目錄號：
HY-P1717
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